Enzymes Recombinant Proteins
Human BDH2 Recombinant Protein (RPPB1442)
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- SKU:
- RPPB1442
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BUT1
- Research Area:
- Enzymes
Description
| Product Name: | Human BDH2 Recombinant Protein |
| Product Code: | RPPB1442 |
| Size: | 20µg |
| Species: | Human |
| Target: | BDH2 |
| Synonyms: | 3-hydroxybutyrate dehydrogenase type 2, FLJ13261, PRO20933, SDR15C1, UCPA-OR, UNQ6308, dehydrogenase/reductase (SDR family) member 6, Oxidoreductase UCPA, DHRS6, R-beta-hydroxybutyrate dehydrogenase, EFA6R, EC 1.1.1.30. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The BDH2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID GGWSL |
BDH2 is a member of the short-chain dehydrogenases/reductases (SDR) family. BDH2 protein has a significant part in the peripheral utilization of 3-hydroxybutyrate. BDH2 can convert high levels of circulating 3-hydroxybutyrate into acetoacetate due to cytoplasmic localization in high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters.
BDH2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-245a.a.) and having a molecular mass of 28.8kDa.BDH2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BUT1 |
| NCBI GenInfo Identifier: | 66933014 |
| NCBI Gene ID: | 56898 |
| NCBI Accession: | NP_064524 |
| UniProt Secondary Accession: | Q9BUT1,Q503A0, Q6IA46, Q6UWD3, Q9H8S8, Q9NRX8, A8K295 B4DUF6 |
| UniProt Related Accession: | Q9BUT1 |
| Molecular Weight: | 28.8 kDa (265aa), confirmed by MALDI-TOF |
| NCBI Full Name: | 3-hydroxybutyrate dehydrogenase type 2 |
| NCBI Synonym Full Names: | 3-hydroxybutyrate dehydrogenase 2 |
| NCBI Official Symbol: | BDH2�� |
| NCBI Official Synonym Symbols: | DHRS6; EFA6R; SDR15C1; UCPA-OR; UNQ6308; PRO20933�� |
| NCBI Protein Information: | 3-hydroxybutyrate dehydrogenase type 2 |
| UniProt Protein Name: | 3-hydroxybutyrate dehydrogenase type 2 |
| UniProt Synonym Protein Names: | Dehydrogenase/reductase SDR family member 6; Oxidoreductase UCPA; R-beta-hydroxybutyrate dehydrogenase; Short chain dehydrogenase/reductase family 15C member 1 |
| Protein Family: | Probable diacetyl reductase |
| UniProt Gene Name: | BDH2�� |
| UniProt Entry Name: |
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