Cytokines Recombinant Proteins

Human BD 2 Recombinant Protein (RPPB0071)

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SKU:
RPPB0071
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O15263
Research Area:
Cytokines

Description

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Product Name:Human BD 2 Recombinant Protein
Product Code:RPPB0071
Size:20µg
Species:Human
Target:BD 2
Synonyms:BD-2, hBD-2, Defensin beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB4, DEFB102, DEFB2, DEFB4P, Beta-defensin 2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The Human BD-2 was lyophilized from a 0.2�m filtered concentrated (1mg/ml) solution containing 20mM PB pH-7.4 and 130mM NaCl.
Solubility:It is recommended to reconstitute the lyophilized Beta Defensin-2 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Beta Defensin-2 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-2 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
Biological Activity:Determined by the ability to chemoattract human dendritic immature cells at a concentration of 10-100ng/ml.

The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. BBeta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis. Variation in human Beta Defensin-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human Beta Defensin-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. The expression of Human BD1 is correlated with induction profiles in gingival keratinocytes. The level of expression of human DEFB1 mRNA is lower than that of human BD3 and human BD-2 in reconstructed epidermis.Human BD1 is down-regulated in human prostatic and renal carcinomas.

Beta Defensin-2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 41 amino acids and having a molecular mass of 4.3 kDa. The BD-2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:defensin, beta 2: Has antibacterial activity (Potential). Belongs to the beta-defensin family. LAP/TAP subfamily.
UniProt Protein Details:

Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: Golgi lumen; extracellular region

Biological Process: G-protein coupled receptor protein signaling pathway; defense response to bacterium; innate immune response; immune response; chemotaxis

NCBI Summary:Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
UniProt Code:O15263
NCBI GenInfo Identifier:3023383
NCBI Gene ID:100289462
NCBI Accession:O15263.1
UniProt Secondary Accession:O15263,Q52LC0,
Molecular Weight:7,038 Da
NCBI Full Name:Beta-defensin 4A
NCBI Synonym Full Names:defensin, beta 4B
NCBI Official Symbol:DEFB4B��
NCBI Official Synonym Symbols:DEFB4P��
NCBI Protein Information:beta-defensin 4B; defensin, beta 4, pseudogene
UniProt Protein Name:Beta-defensin 4A
UniProt Synonym Protein Names:Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1; SAP1
UniProt Gene Name:DEFB4A��
UniProt Entry Name:DFB4A_HUMAN
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