Human BCL7A Recombinant Protein (RPPB2876)

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SKU:
RPPB2876
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q4VC05

Description

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Product Name:Human BCL7A Recombinant Protein
Product Code:RPPB2876
Size:10µg
Species:Human
Target:BCL7A
Synonyms:B-cell CLL/lymphoma 7 protein family member A, BCL7A, BCL7.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:BCL7A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol, 1mM DTT and 2mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSGRSVR AETRSRAKDD IKRVMAAIEK VRKWEKKWVT VGDTSLRIYK WVPVTEPKVD DKNKNKKKGK DEKCGSEVTT PENSSSPGMM DMHDDNSNQS SIADASPIKQ ENSSNSSPAP EPNSAVPSDG TEAKVDEAQA DGKEHPGAED ASDEQNSQSS MEHSMNSSEK VDRQPSGDSG LAAETSAISQ DLEGVPPSKK MKLEASQQNS EEM

B-cell CLL/lymphoma 7A (BCL7A) is a member of the BCL7 family. BCL7A is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. Thru gene translocation, the N-terminal region of the BCL7A gene is disrupted, which is assumed to be connected to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal portion involved in the translocation includes the region which shares a compelling sequence similarity with those of BCL7B and BCL7C. Chromosomal anomalies involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma.

BCL7A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (1-210 a.a.) and having a molecular mass of 25.2kDa (Molecular size on SDS-PAGE will appear higher).BCL7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Bcl-7A: Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions. Belongs to the BCL7 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Actin-bindingChromosomal Location of Human Ortholog: 12q24.13Molecular Function: protein binding
UniProt Protein Details:
NCBI Summary:This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q4VC05
NCBI GenInfo Identifier:74754614
NCBI Gene ID:605
NCBI Accession:Q4VC05.1
UniProt Secondary Accession:Q4VC05,Q13843, Q14CT7, B4DJN6, B7ZB21
UniProt Related Accession:Q4VC05
Molecular Weight:25,029 Da
NCBI Full Name:B-cell CLL/lymphoma 7 protein family member A
NCBI Synonym Full Names:BCL tumor suppressor 7A
NCBI Official Symbol:BCL7A��
NCBI Official Synonym Symbols:BCL7��
NCBI Protein Information:B-cell CLL/lymphoma 7 protein family member A
UniProt Protein Name:B-cell CLL/lymphoma 7 protein family member A
UniProt Synonym Protein Names:
Protein Family:B-cell CLL/lymphoma 7 protein family
UniProt Gene Name:BCL7A��
UniProt Entry Name:BCL7A_HUMAN
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