Cell Death Recombinant Proteins

Human BCL2L1/Bcl-XL Recombinant Protein (RPES4389)

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SKU:
RPES4389
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Death

Description

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Human BCL2L1/Bcl-XL Recombinant Protein

Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.

Product Name:Human BCL2L1/Bcl-XL Recombinant Protein (RPES4389)
Product Code:RPES4389
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Bcl-2-Like Protein 1, Bcl2-L-1, Apoptosis Regulator Bcl-X, Bcl-X,bcl-xL,BCL-XL/S,bcl-xS,BCL2L,BCLX,BCLXL,BCLXS,PPP1R52
Accession:Q07817
Sequence:Met1-Arg212
Fusion tag:C-His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human BCL2L1 is produced by our E.coli expression system and the target gene encoding Met1-Arg212 is expressed with a 6His tag at the C-terminus.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:24.85 kDa
AP Mol Mass:29 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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