Human BCL2A1 Recombinant Protein (RPPB2870)

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RPPB2870

Description

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Product Name:Human BCL2A1 Recombinant Protein
Product Code:RPPB2870
Size:10µg
Species:Human
Target:BCL2A1
Synonyms:BCL2-related protein A1, Hemopoietic-specific early response protein, hematopoietic BCL2-related protein A1, Bcl-2-like protein 5, Protein BFL-1, BCL2L5, Protein GRS, HBPA1, ACC-1, ACC-2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The BCL2A1 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMTDCEF GYIYRLAQDY LQYVLQIPQP GSGPSKTSRV LQKVAFSVQK EVEKNLKSCL DNVNVVSVDT ARTLFNQVME KEFEDDIINW GRIVTIFAFE GILIKKLLRQ QIAPDVDTYK EISYFVAEFI MNNTGEWIRQ NGGWENGFVK KFEPKS

BCL2A1 delays apoptosis induced by IL-3 deficiency. BCL2A1 takes part in the response of hemopoietic cells to external signals and in preserving endothelial survival during infection.

BCL2A1 Human Recombinant produced in E. coli is a single polypeptide chain containing 176 amino acids (1-152) and having a molecular mass of 20.2kDa.BCL2A1 is fused to a 24 amino acid His-tag at N-terminus & purified by conventional chromatography.

UniProt Protein Function:BCL2A1: Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Interacts directly with BAK1, BID, BMF and BBC3. Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors. Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: mitochondrial outer membrane

Molecular Function:BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q16548
NCBI GenInfo Identifier:2493280
NCBI Gene ID:597
NCBI Accession:Q16548.1
UniProt Related Accession:Q16548
Molecular Weight:
NCBI Full Name:Bcl-2-related protein A1
NCBI Synonym Full Names:BCL2 related protein A1
NCBI Official Symbol:BCL2A1��
NCBI Official Synonym Symbols:GRS; ACC1; ACC2; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5��
NCBI Protein Information:bcl-2-related protein A1
UniProt Protein Name:Bcl-2-related protein A1
UniProt Synonym Protein Names:Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
UniProt Gene Name:BCL2A1��
UniProt Entry Name:B2LA1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16548
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