Human BATF3 Recombinant Protein (RPPB2853)

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SKU:
RPPB2853
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NR55

Description

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Product Name:Human BATF3 Recombinant Protein
Product Code:RPPB2853
Size:10µg
Species:Human
Target:BATF3
Synonyms:JDP1, JUNDM1, SNFT, Basic leucine zipper transcriptional factor ATF-like 3, B-ATF-3, 21 kDa small nuclear factor isolated from T-cells, Jun dimerization protein p21SNFT, BATF3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:BATF3 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSQGLPA AGSVLQRSVA APGNQPQPQP QQQSPEDDDR KVRRREKNRV AAQRSRKKQT QKADKLHEEY ESLEQENTML RREIGKLTEE LKHLTEALKE HEKMCPLLLC PMNFVPVPPR PDPVAGCLPR

Basic Leucine Zipper Transcription Factor ATF-Like 3 (BATF3) which is localizes to the nucleus, contains 1 bZIP domain. BATF3 functions as a negative regulator of AP-1-mediated transcription when interacting with c-Jun, particularly by heterodimerizing with c-Jun and binding to DNA response elements. BATF3 also takes part in repression of interleukin-2.

BATF3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 150 amino acids (1-127 a.a) and having a molecular mass of 16.9kDa. BATF3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:BATF3: Functions as a negative regulator of AP-1-mediated transcription by heterodimerizing with JUN and binding DNA at 12- O-tetradecanoylphorbol-13-acetate response elements (TRE) (consensus: 5'-TGA[CG]TCA-3'). Represses IL2 and MMP1 promoter activities. Belongs to the bZIP family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1q32.3

Cellular Component: nucleus

Molecular Function:protein binding; transcription corepressor activity; transcription factor activity

Biological Process: myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; response to virus; transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009]
UniProt Code:Q9NR55
NCBI GenInfo Identifier:74752916
NCBI Gene ID:55509
NCBI Accession:Q9NR55.1
UniProt Secondary Accession:Q9NR55,Q9D275, P97876,
UniProt Related Accession:Q9NR55
Molecular Weight:14,468 Da
NCBI Full Name:Basic leucine zipper transcriptional factor ATF-like 3
NCBI Synonym Full Names:basic leucine zipper ATF-like transcription factor 3
NCBI Official Symbol:BATF3��
NCBI Official Synonym Symbols:JDP1; SNFT; JUNDM1��
NCBI Protein Information:basic leucine zipper transcriptional factor ATF-like 3
UniProt Protein Name:Basic leucine zipper transcriptional factor ATF-like 3
UniProt Synonym Protein Names:21 kDa small nuclear factor isolated from T-cells; Jun dimerization protein p21SNFT
Protein Family:Basic leucine zipper transcriptional factor
UniProt Gene Name:BATF3��
UniProt Entry Name:BATF3_HUMAN
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