Description
| Product Name: | Human BATF3 Recombinant Protein |
| Product Code: | RPPB2853 |
| Size: | 10µg |
| Species: | Human |
| Target: | BATF3 |
| Synonyms: | JDP1, JUNDM1, SNFT, Basic leucine zipper transcriptional factor ATF-like 3, B-ATF-3, 21 kDa small nuclear factor isolated from T-cells, Jun dimerization protein p21SNFT, BATF3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | BATF3 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSQGLPA AGSVLQRSVA APGNQPQPQP QQQSPEDDDR KVRRREKNRV AAQRSRKKQT QKADKLHEEY ESLEQENTML RREIGKLTEE LKHLTEALKE HEKMCPLLLC PMNFVPVPPR PDPVAGCLPR |
Basic Leucine Zipper Transcription Factor ATF-Like 3 (BATF3) which is localizes to the nucleus, contains 1 bZIP domain. BATF3 functions as a negative regulator of AP-1-mediated transcription when interacting with c-Jun, particularly by heterodimerizing with c-Jun and binding to DNA response elements. BATF3 also takes part in repression of interleukin-2.
BATF3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 150 amino acids (1-127 a.a) and having a molecular mass of 16.9kDa. BATF3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BATF3: Functions as a negative regulator of AP-1-mediated transcription by heterodimerizing with JUN and binding DNA at 12- O-tetradecanoylphorbol-13-acetate response elements (TRE) (consensus: 5'-TGA[CG]TCA-3'). Represses IL2 and MMP1 promoter activities. Belongs to the bZIP family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1q32.3 Cellular Component: nucleus Molecular Function:protein binding; transcription corepressor activity; transcription factor activity Biological Process: myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; response to virus; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the basic leucine zipper protein family. The encoded protein functions as a transcriptional repressor when heterodimerizing with JUN. The protein may play a role in repression of interleukin-2 and matrix metalloproteinase-1 transcription.[provided by RefSeq, Feb 2009] |
| UniProt Code: | Q9NR55 |
| NCBI GenInfo Identifier: | 74752916 |
| NCBI Gene ID: | 55509 |
| NCBI Accession: | Q9NR55.1 |
| UniProt Secondary Accession: | Q9NR55,Q9D275, P97876, |
| UniProt Related Accession: | Q9NR55 |
| Molecular Weight: | 14,468 Da |
| NCBI Full Name: | Basic leucine zipper transcriptional factor ATF-like 3 |
| NCBI Synonym Full Names: | basic leucine zipper ATF-like transcription factor 3 |
| NCBI Official Symbol: | BATF3�� |
| NCBI Official Synonym Symbols: | JDP1; SNFT; JUNDM1�� |
| NCBI Protein Information: | basic leucine zipper transcriptional factor ATF-like 3 |
| UniProt Protein Name: | Basic leucine zipper transcriptional factor ATF-like 3 |
| UniProt Synonym Protein Names: | 21 kDa small nuclear factor isolated from T-cells; Jun dimerization protein p21SNFT |
| Protein Family: | Basic leucine zipper transcriptional factor |
| UniProt Gene Name: | BATF3�� |
| UniProt Entry Name: | BATF3_HUMAN |
