Human ATP5C1 Recombinant Protein (RPPB2823)
- SKU:
- RPPB2823
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P36542
Description
| Product Name: | Human ATP5C1 Recombinant Protein |
| Product Code: | RPPB2823 |
| Size: | 20µg |
| Species: | Human |
| Target: | ATP5C1 |
| Synonyms: | ESE3, ESE3B, ESEJ, F-ATPase gamma subunit, ATP5C1, ATP5CL1, ATP5C, ATP synthase subunit gamma, mitochondrial. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | ATP5C1 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSATLKDIT RRLKSIKNIQ KITKSMKMVA AAKYARAERE LKPARIYGLG SLALYEKADI KGPEDKKKHL LIGVSSDRGL CGAIHSSIAK QMKSEVATLT AAGKEVMLVG IGDKIRGILY RTHSDQFLVA FKEVGRKPPT FGDASVIALE LLNSGYEFDE GSIIFNKFRS VISYKTEEKP IFSLNTVASA DSMSIYDDID ADVLQNYQEY NLANIIYYSL KESTTSEQSA RMTAMDNASK NASEMIDKLT LTFNRTRQAV ITKELIEIIS GAAALD |
ATP synthase subunit gamma, mitochondrial isoform L (liver) (ATP5C1) is a member of the ATPase gamma chain family. ATP5C1 catalyzes ATP synthesis by using an electrochemical gradient of protons across the inner membrane throughout oxidative phosphorylation. The catalytic portion of mitochondrial ATP synthase is comprised of 5 different subunits (alpha, beta, gamma, delta, and epsilon) gathered with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3.
ATP5C1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 296 amino acids (26-298 a.a.) and having a molecular mass of 32.6kDa.ATP5C1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ATP5C: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Belongs to the ATPase gamma chain family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Energy Metabolism - oxidative phosphorylation; Mitochondrial; Hydrolase; EC 3.6.3.14 Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: membrane; mitochondrial inner membrane; mitochondrial matrix; mitochondrial proton-transporting ATP synthase complex; mitochondrion; myelin sheath Molecular Function:ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism; transmembrane transporter activity Biological Process: ATP biosynthetic process; cellular metabolic process; mitochondrial ATP synthesis coupled proton transport; oxidative phosphorylation |
| NCBI Summary: | This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P36542 |
| NCBI GenInfo Identifier: | 543875 |
| NCBI Gene ID: | 509 |
| NCBI Accession: | P36542.1 |
| UniProt Secondary Accession: | P36542,Q5VYP3, Q6I9V2, Q96AS8, A8KA31, |
| UniProt Related Accession: | P36542 |
| Molecular Weight: | 32,881 Da |
| NCBI Full Name: | ATP synthase subunit gamma, mitochondrial |
| NCBI Synonym Full Names: | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 |
| NCBI Official Symbol: | ATP5C1�� |
| NCBI Official Synonym Symbols: | ATP5C; ATP5CL1�� |
| NCBI Protein Information: | ATP synthase subunit gamma, mitochondrial |
| UniProt Protein Name: | ATP synthase subunit gamma, mitochondrial |
| UniProt Synonym Protein Names: | F-ATPase gamma subunit |
| UniProt Gene Name: | ATP5C1�� |
| UniProt Entry Name: | ATPG_HUMAN |
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