Human ATP1B3 Recombinant Protein (RPPB2822)
- SKU:
- RPPB2822
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P54709
Description
| Product Name: | Human ATP1B3 Recombinant Protein |
| Product Code: | RPPB2822 |
| Size: | 10µg |
| Species: | Human |
| Target: | ATP1B3 |
| Synonyms: | ATPase Na+/K+ Transporting Beta 3 Polypeptide, Sodium-Potassium ATPase Subunit Beta 3 (Non-Catalytic), Sodium/Potassium-Transporting ATPase Subunit Beta-3, Sodium/Potassium-Dependent ATPase Subunit Beta-3, Sodium Pump Subunit Beta-3, ATPB-3, Sodium/Potassium-Transporting ATPase Beta-3 Chain, Sodium/Potassium-Dependent ATPase Beta-3 Subunit, Na K-ATPase Beta-3 Polypeptide, CD298 Antigen, CD298, ATP1B3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ATP1B3 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTMWVMLQ TLNDEVPKYR DQIPSPGLMV FPKPVTALEY TFSRSDPTSY AGYIEDLKKF LKPYTLEEQK NLTVCPDGAL FEQKGPVYVA CQFPISLLQA CSGMNDPDFG YSQGNPCILV KMNRIIGLKP EGVPRIDCVS KNEDIPNVAV YPHNGMIDLK YFPYYGKKLH VGYLQPLVAV QVSFAPNNTG KEVTVECKID GSANLKSQDD RDKFLGRVMF KITARA |
ATPaseTransporting Beta 3 (ATP1B3) is a member of the X(+)/potassium ATPases subunit beta family. ATP1B3 is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit controls, by way of assembly of alpha/beta heterodimers, the quantity of sodium pumps transported to the plasma membrane. The precise role of the beta-3 subunit is unknown.
ATP1B3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 246 amino acids (57-279) and having a molecular mass of 27.4 kDa.ATP1B3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ATP1B3: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family.Protein type: Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 3q23Cellular Component: plasma membrane; sodium:potassium-exchanging ATPase complexMolecular Function: ATPase activator activity; ATPase binding; sodium:potassium-exchanging ATPase activityBiological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transport |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P54709 |
| NCBI GenInfo Identifier: | 1703470 |
| NCBI Gene ID: | 483 |
| NCBI Accession: | P54709.1 |
| UniProt Secondary Accession: | P54709,B7Z1N7 |
| UniProt Related Accession: | P54709 |
| Molecular Weight: | 21,713 Da |
| NCBI Full Name: | Sodium/potassium-transporting ATPase subunit beta-3 |
| NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit beta 3 |
| NCBI Official Symbol: | ATP1B3�� |
| NCBI Official Synonym Symbols: | CD298; ATPB-3�� |
| NCBI Protein Information: | sodium/potassium-transporting ATPase subunit beta-3 |
| UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit beta-3 |
| UniProt Synonym Protein Names: | Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD_antigen: CD298 |
| Protein Family: | |
| UniProt Gene Name: | ATP1B3�� |
| UniProt Entry Name: | AT1B3_HUMAN |
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