Human ATP1B2 Recombinant Protein (RPPB2821)
- SKU:
- RPPB2821
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P14415
Description
| Product Name: | Human ATP1B2 Recombinant Protein |
| Product Code: | RPPB2821 |
| Size: | 10µg |
| Species: | Human |
| Target: | ATP1B2 |
| Synonyms: | ATP1B2, AMOG, Sodium/Potassium-Transporting ATPase Beta-2Chain, Sodium/Potassium-Dependent ATPase Beta-2 Subunit, Na, K-ATPase Beta-2Polypeptide, Adhesion Molecule On Glia, ATPase Na+/K+ Transporting Subunit Beta2, Sodium-Potassium ATPase Subunit Beta 2 (Non-Catalytic),Sodium/Potassium-Transporting ATPase Subunit Beta-2, Sodium/Potassium-DependentATPase Subunit Beta-2, ATPase, Na+/K+ Transporting, Beta 2 Polypeptide, SodiumPump Subunit Beta-2, Adhesion Molecule In Glia. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ATP1B2 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPDHTPKYQ DRLATPGLMI RPKTENLDVI VNVSDTESWD QHVQKLNKFL EPYNDSIQAQ KNDVCRPGRY YEQPDNGVLN YPKRACQFNR TQLGNCSGIG DSTHYGYSTG QPCVFIKMNR VINFYAGANQ SMNVTCAGKR DEDAENLGNF VMFPANGNID LMYFPYYGKK FHVNYTQPLV AVKFLNVTPN VEVNVECRIN AANIATDDER DKFAGRVAFK LRINKTHHHH HH |
ATPaseTransporting Beta 2 (ATP1B2) is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The precise function of the beta-2 subunit is not known. The ATP1B2 protein is composed of 3 subunits: alpha (catalytic), beta and gamma.
ATP1B2 Human Recombinant produced in Sf9 Baculoviruscells is a single, glycosylated polypeptide chain containing 232 amino acids (68-290a.a.)and having a molecular mass of 26.4kDa (Molecular size on SDS-PAGE will appearat approximately 28-40 kDa). ATP1B2 is expressed with a 9 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ATP1B2: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: plasma membrane; sodium:potassium-exchanging ATPase complex Molecular Function:ATPase activator activity; ATPase binding; protein binding; sodium:potassium-exchanging ATPase activity Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transport |
| NCBI Summary: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P14415 |
| NCBI GenInfo Identifier: | 125987795 |
| NCBI Gene ID: | 482 |
| NCBI Accession: | P14415.3 |
| UniProt Secondary Accession: | P14415,O60444, A0AV17, A8K278, D3DTQ2, |
| UniProt Related Accession: | P14415 |
| Molecular Weight: | 33,367 Da |
| NCBI Full Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
| NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit beta 2 |
| NCBI Official Symbol: | ATP1B2�� |
| NCBI Official Synonym Symbols: | AMOG�� |
| NCBI Protein Information: | sodium/potassium-transporting ATPase subunit beta-2 |
| UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
| UniProt Synonym Protein Names: | Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2 |
| Protein Family: | Sodium/potassium-transporting ATPase |
| UniProt Gene Name: | ATP1B2�� |
| UniProt Entry Name: | AT1B2_HUMAN |
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