Human ATP1B2 Recombinant Protein (RPPB2820)
- SKU:
- RPPB2820
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P14415
Description
| Product Name: | Human ATP1B2 Recombinant Protein |
| Product Code: | RPPB2820 |
| Size: | 20µg |
| Species: | Human |
| Target: | ATP1B2 |
| Synonyms: | ATPase Na+/K+ Transporting Beta 2 Polypeptide, Sodium-Potassium ATPase Subunit Beta 2 (Non-Catalytic), Sodium/Potassium-Dependent ATPase Beta-2 Subunit, Sodium/Potassium-Transporting ATPase Beta-2 Chain, Adhesion Molecule On Glia, Na K-ATPase Beta-2 Polypeptide, Sodium Pump Subunit Beta-2, AMOG. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The ATP1B2 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSDHTPKYQ DRLATPGLMI RPKTENLDVI VNVSDTESWD QHVQKLNKFL EPYNDSIQAQ KNDVCRPGRY YEQPDNGVLN YPKRACQFNR TQLGNCSGIG DSTHYGYSTG QPCVFIKMNR VINFYAGANQ SMNVTCAGKR DEDAENLGNF VMFPANGNID LMYFPYYGKK FHVNYTQPLV AVKFLNVTPN VEVNVECRIN AANIATDDER DKFAGRVAFK LRINKT |
ATPaseTransporting Beta 2 (ATP1B2) is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The precise function of the beta-2 subunit is not known. The ATP1B2 protein is composed of 3 subunits: alpha (catalytic), beta and gamma.
ATP1B2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 246 amino acids (68-246) and having a molecular mass of 27.8kDa.ATP1B2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ATP1B2: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Belongs to the X(+)/potassium ATPases subunit beta family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: plasma membrane; sodium:potassium-exchanging ATPase complex Molecular Function:ATPase activator activity; ATPase binding; protein binding; sodium:potassium-exchanging ATPase activity Biological Process: cellular potassium ion homeostasis; cellular sodium ion homeostasis; leukocyte migration; positive regulation of ATPase activity; potassium ion import; protein stabilization; transport |
| NCBI Summary: | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P14415 |
| NCBI GenInfo Identifier: | 125987795 |
| NCBI Gene ID: | 482 |
| NCBI Accession: | P14415.3 |
| UniProt Secondary Accession: | P14415,O60444, A0AV17, A8K278, D3DTQ2, |
| UniProt Related Accession: | P14415 |
| Molecular Weight: | 33,367 Da |
| NCBI Full Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
| NCBI Synonym Full Names: | ATPase Na+/K+ transporting subunit beta 2 |
| NCBI Official Symbol: | ATP1B2�� |
| NCBI Official Synonym Symbols: | AMOG�� |
| NCBI Protein Information: | sodium/potassium-transporting ATPase subunit beta-2 |
| UniProt Protein Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
| UniProt Synonym Protein Names: | Adhesion molecule in glia; AMOG; Sodium/potassium-dependent ATPase subunit beta-2 |
| Protein Family: | Sodium/potassium-transporting ATPase |
| UniProt Gene Name: | ATP1B2�� |
| UniProt Entry Name: | AT1B2_HUMAN |
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