Human ATOH1 Recombinant Protein (RPPB2815)
- SKU:
- RPPB2815
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q92858
Description
| Product Name: | Human ATOH1 Recombinant Protein |
| Product Code: | RPPB2815 |
| Size: | 20µg |
| Species: | Human |
| Target: | ATOH1 |
| Synonyms: | Atonal homolog 1 (Drosophila), Helix-loop-helix protein hATH-1, Class A basic helix-loop-helix protein 14, bHLHa14, HATH1, Math1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ATOH1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKQRRLAANA RERRRMHGLN HAFDQLRNVI PSFNNDKKLS KYETLQMAQI YINALSELLQ TPSGGEQPPP PPASCKSDHH HLRTAASYEG GAGNATAAGA QQASGGSQRP TPPGSCRTRF SAPASAGGYS VQLDALHFST FEDSALTAMM AQKNLSPSLP GSILQPVQEE NSKTSPRSHR SDGEFSPHSH YSDSDEAS |
ATOH1 activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is entirely provoked by the negative regulator of neurogenesis HES1. ATOH1 takes part in the differentiation of divisions of neural cells by activating E box-dependent transcription.
ATOH1 Human Recombinant produced in E. coli is a single polypeptide chain containing 198 amino acids (158-354) and having a molecular mass of 21.3kDa.ATOH1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription. Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 4q22 Cellular Component: nucleus Molecular Function:transcription factor activity Biological Process: central nervous system development; positive regulation of neuron differentiation |
| NCBI Summary: | This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92858 |
| NCBI GenInfo Identifier: | 3913115 |
| NCBI Gene ID: | 474 |
| NCBI Accession: | Q92858.1 |
| UniProt Secondary Accession: | Q92858,Q14CT9, |
| UniProt Related Accession: | Q92858 |
| Molecular Weight: | 38,160 Da |
| NCBI Full Name: | Protein atonal homolog 1 |
| NCBI Synonym Full Names: | atonal bHLH transcription factor 1 |
| NCBI Official Symbol: | ATOH1�� |
| NCBI Official Synonym Symbols: | ATH1; HATH1; MATH-1; bHLHa14�� |
| NCBI Protein Information: | protein atonal homolog 1 |
| UniProt Protein Name: | Protein atonal homolog 1 |
| UniProt Synonym Protein Names: | Class A basic helix-loop-helix protein 14; bHLHa14; Helix-loop-helix protein hATH-1; hATH1 |
| Protein Family: | Protein atonal |
| UniProt Gene Name: | ATOH1�� |
| UniProt Entry Name: | ATOH1_HUMAN |
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