Human Ataxin-3/ATXN3 Recombinant Protein (His tag)
- SKU:
- RPES5575
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
| Product Name: | Human Ataxin-3/ATXN3 Recombinant Protein (His tag) |
| Product Code: | RPES5575 |
| Size: | 20µg |
| Species: | Human |
| Expression Host: | E.coli |
| Synonyms: | Ataxin-3, ATXN3, Machado-Joseph disease protein1, Spinocerebellar ataxia type 3 protein |
| Mol Mass: | 40.59 kDa |
| AP Mol Mass: | 50 kDa |
| Tag: | N-His & C-His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Met 1-Lys 370 |
| Accession: | P54252-2 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Ataxin-3 is a ubiquitously expressed nuclear protein that serves as a deubiquitinating enzyme (DUB) involved in protein homeostasis and quality control, myogenesis and degradation of misfolded chaperone substrates. As a DUB, it has two distinct features. Its N-terminal Josephin domain confers cysteine protease activity to Ataxin-3 which is important for hydrolyzing ubiquitin (Ub) linkages. The second important feature is its three Ub-interacting motifs (UIMs) through which it binds Ub conjugates and ubiquitinated proteins and bring them into proximity to trim or edit specific linkages within these Ub conjugates. It binds long poly-Ub chains and trims them. However, it has weak or no activity against chains of 4 or less Ub. |
Related Products
Human SDHA Recombinant Protein (His tag)
OverviewProduct Name:Human SDHA Recombinant Protein (His tag)Product Code:RPES5594Size:20µgSpecies:HumanExpress
Human KLK3 Recombinant Protein (His tag)
OverviewProduct Name:Human KLK3 Recombinant Protein (His tag)Product Code:RPES5551Size:20µgSpecies:HumanExpress
Human CFHR1 Recombinant Protein (His tag)
OverviewProduct Name:Human CFHR1 Recombinant Protein (His tag)Product Code:RPES5424Size:20µgSpecies:HumanExpres
Human CDK5RAP3 Recombinant Protein (His tag)
OverviewProduct Name:Human CDK5RAP3 Recombinant Protein (His tag)Product Code:RPES5674Size:20µgSpecies:HumanExp