Human ASB13 Recombinant Protein (RPPB2803)

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SKU:
RPPB2803
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WXK3

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human ASB13 Recombinant Protein
Product Code:RPPB2803
Size:20µg
Species:Human
Target:ASB13
Synonyms:Ankyrin repeat and SOCS box protein 13, ASB-13, ASB13, ankyrin repeat and SOCS box containing 13.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:ASB13 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEPRAAD GCFLGDVGFW VERTPVHEAA QRGESLQLQQ LIESGACVNQ VTVDSITPLH AASLQGQARC VQLLLAAGAQ VDARNIDGST PLCDACASGS IECVKLLLSY GAKVNPPLYT ASPLHEACMS GSSECVRLLI DVGANLEAHD CHFGTPLHVA CAREHLDCVK VLLNAGANVN AAKLHETALH HAAKVKNVDL IEMLIEFGGN IYARDNRGKK PSDYTWSSSA PAKCFEYYEK TPLTLSQLCR VNLRKATGVR GLEKIAKLNI PPRLIDYLSY N

ASB13 belongs to the ankyrin repeat and SOCS box-containing (ASB) family of proteins which contains ankyrin repeat sequence and a SOCS box domain. ASB13 is a protein coding gene that plays a role as a substrate-recognition part of a SCF-like ECS E3 ubiquitin-protein ligase complex which arbitrates the ubiquitination and subsequent proteasomal degradation of target proteins.

ASB13 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 301 amino acids (1-278 a.a.) and having a molecular mass of 32.4kDa.ASB13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ASB13: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 10p15.1

Molecular Function:protein binding

Biological Process: protein ubiquitination

NCBI Summary:The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]
UniProt Code:Q8WXK3
NCBI GenInfo Identifier:22208957
NCBI Gene ID:79754
NCBI Accession:NP_078977.2
UniProt Secondary Accession:Q8WXK3,Q96EP7, Q9H8Z1, A8K7Q6, D3DRR2,
UniProt Related Accession:Q8WXK3
Molecular Weight:18,205 Da
NCBI Full Name:ankyrin repeat and SOCS box protein 13
NCBI Synonym Full Names:ankyrin repeat and SOCS box containing 13
NCBI Official Symbol:ASB13��
NCBI Protein Information:ankyrin repeat and SOCS box protein 13; ankyrin repeat and SOCS box-containing 13; ankyrin repeat domain-containing SOCS box protein Asb-13
UniProt Protein Name:Ankyrin repeat and SOCS box protein 13
Protein Family:Ankyrin repeat and SOCS box protein
UniProt Gene Name:ASB13��
UniProt Entry Name:ASB13_HUMAN
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