Human Artemin Recombinant Protein (RPES4456)

Human Artemin Recombinant Protein

Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. The mature protein is produced as a preproprotein, which contains a variable-length pre-, or signal sequence, as well as a 68-amino acid (aa) prodomain and a 113-aa mature segment. Mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-beta signature cysteine-knot motif after synthesis and proteolytic processing. In the adult period, human ARTN is 89% aa identical to rat and mouse ARTN, respectively. Human ARTN is active on rodent cells. The receptor for ARTHN has been identified as GFR-3 and the signal transducing subunit, RET. The GFR-1/RET receptor complex has also been suggested to be a ligand binding unit for ARTN. ARTN is known to be a chemoattractant for sympathetic neuron axons innervating the developing cardiovascular system. It also promotes sensory neuron survival and likely plays a role in the development of the peripheral nervous system. Finally, it has been reported to reverse neuropathic pain due to nerve injury, and to help resolve morphological changes associated with nerve damage. Human Artemin Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.