Human ARPP19 Recombinant Protein (RPPB2801)

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RPPB2801

Description

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Product Name:Human ARPP19 Recombinant Protein
Product Code:RPPB2801
Size:20µg
Species:Human
Target:ARPP19
Synonyms:CAMP-Regulated Phosphoprotein 19kDa, ARPP-19, ARPP16, Endosulfine Alpha-Like, ARPP-16, ENSAL, CAMP-Regulated Phosphoprotein 19, Cyclic AMP Phosphoprotein 19 KD, ARPP19.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ARPP19 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSAEVPE AASAEEQKEM EDKVTSPEKA EEAKLKARYP HLGQKPGGSD FLRKRLQKGQ KYFDSGDYNM AKAKMKNKQL PTAAPDKTEV TGDHIPTPQD LPQRKPSLVA SKLAG

cAMP-regulated phosphoprotein 19 (ARPP19) is protein phosphatase inhibitor which specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, ARPP19 specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, a vital condition to maintain cyclin-B1-CDK1 activity high during M phase. ARPP19 protein may indirectly boost GAP-43 expression. The 19 kDa cAMP-regulated phosphoprotein has a role in regulating mitosis by obstructing protein phosphatase-2A.

ARPP19 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 135 amino acids (1-112 a.a) and having a molecular mass of 14.7kDa.ARPP19 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
UniProt Protein Details:
NCBI Summary:The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]
UniProt Code:P56211
NCBI GenInfo Identifier:5729732
NCBI Gene ID:10776
NCBI Accession:NP_006619
UniProt Secondary Accession:P56211
UniProt Related Accession:P56211
Molecular Weight:
NCBI Full Name:cAMP-regulated phosphoprotein 19 isoform 2
NCBI Synonym Full Names:cAMP regulated phosphoprotein 19
NCBI Official Symbol:ARPP19��
NCBI Official Synonym Symbols:ENSAL; ARPP16; ARPP-16; ARPP-19��
NCBI Protein Information:cAMP-regulated phosphoprotein 19
UniProt Protein Name:cAMP-regulated phosphoprotein 19
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:ARPP19��
UniProt Entry Name:
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P56211
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