Human ARPP19 Recombinant Protein (RPPB2801)
- SKU:
- RPPB2801
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P56211
Description
| Product Name: | Human ARPP19 Recombinant Protein |
| Product Code: | RPPB2801 |
| Size: | 20µg |
| Species: | Human |
| Target: | ARPP19 |
| Synonyms: | CAMP-Regulated Phosphoprotein 19kDa, ARPP-19, ARPP16, Endosulfine Alpha-Like, ARPP-16, ENSAL, CAMP-Regulated Phosphoprotein 19, Cyclic AMP Phosphoprotein 19 KD, ARPP19. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ARPP19 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSAEVPE AASAEEQKEM EDKVTSPEKA EEAKLKARYP HLGQKPGGSD FLRKRLQKGQ KYFDSGDYNM AKAKMKNKQL PTAAPDKTEV TGDHIPTPQD LPQRKPSLVA SKLAG |
cAMP-regulated phosphoprotein 19 (ARPP19) is protein phosphatase inhibitor which specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, ARPP19 specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, a vital condition to maintain cyclin-B1-CDK1 activity high during M phase. ARPP19 protein may indirectly boost GAP-43 expression. The 19 kDa cAMP-regulated phosphoprotein has a role in regulating mitosis by obstructing protein phosphatase-2A.
ARPP19 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 135 amino acids (1-112 a.a) and having a molecular mass of 14.7kDa.ARPP19 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. |
| UniProt Protein Details: | |
| NCBI Summary: | The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011] |
| UniProt Code: | P56211 |
| NCBI GenInfo Identifier: | 5729732 |
| NCBI Gene ID: | 10776 |
| NCBI Accession: | NP_006619 |
| UniProt Secondary Accession: | P56211 |
| UniProt Related Accession: | P56211 |
| Molecular Weight: | |
| NCBI Full Name: | cAMP-regulated phosphoprotein 19 isoform 2 |
| NCBI Synonym Full Names: | cAMP regulated phosphoprotein 19 |
| NCBI Official Symbol: | ARPP19�� |
| NCBI Official Synonym Symbols: | ENSAL; ARPP16; ARPP-16; ARPP-19�� |
| NCBI Protein Information: | cAMP-regulated phosphoprotein 19 |
| UniProt Protein Name: | cAMP-regulated phosphoprotein 19 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | ARPP19�� |
| UniProt Entry Name: |
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