Human ARPC5 Recombinant Protein (RPPB2799)

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SKU:
RPPB2799
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O15511

Description

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Product Name:Human ARPC5 Recombinant Protein
Product Code:RPPB2799
Size:20µg
Species:Human
Target:ARPC5
Synonyms:Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, p16-ARC, ARPC5, ARC16, MGC88523, dJ127C7.3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ARPC5 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT V

ARPC5 is a 151 amino acid subunit of the Arp2/3 complex. ARPC5 is believed to have a role in maintaining the integrity of Arp2/3. ARPC5 is a substrate for MAPKAPK-2 which, via phosphorylation of ARPC5, may participate in Arp2/3 regulatory functions and remodeling of the Actin cytoskeleton.

ARPC5 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 171 amino acids (1-151 a.a.) and having a molecular mass of 18.4kDa. The ARPC5 is purified by proprietary chromatographic techniques.

UniProt Protein Function:ARPC5: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Belongs to the ARPC5 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q25.3

Cellular Component: actin cytoskeleton; Arp2/3 protein complex; cytoplasm; cytosol; extracellular region; focal adhesion

Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton

Biological Process: actin cytoskeleton organization and biogenesis; cell migration; cell motility; ephrin receptor signaling pathway; neutrophil degranulation

NCBI Summary:This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Code:O15511
NCBI GenInfo Identifier:3121767
NCBI Gene ID:10092
NCBI Accession:O15511.3
UniProt Secondary Accession:O15511,Q6PG42, A6NEC4,
UniProt Related Accession:O15511
Molecular Weight:16kDa
NCBI Full Name:Actin-related protein 2/3 complex subunit 5
NCBI Synonym Full Names:actin related protein 2/3 complex subunit 5
NCBI Official Symbol:ARPC5��
NCBI Official Synonym Symbols:ARC16; p16-Arc; dJ127C7.3��
NCBI Protein Information:actin-related protein 2/3 complex subunit 5
UniProt Protein Name:Actin-related protein 2/3 complex subunit 5
UniProt Synonym Protein Names:Arp2/3 complex 16 kDa subunit; p16-ARC
UniProt Gene Name:ARPC5��
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