Human ARPC3 Recombinant Protein (RPPB2800)

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SKU:
RPPB2800
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O15145

Description

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Product Name:Human ARPC3 Recombinant Protein
Product Code:RPPB2800
Size:20µg
Species:Human
Target:ARPC3
Synonyms:ARC21, p21-Arc, Actin-related protein 2/3 complex subunit 3, Arp2/3 complex 21 kDa subunit, ARPC3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ARPC3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPAYHSS LMDPDTKLIG NMALLPIRSQ FKGPAPRETK DTDIVDEAIY YFKANVFFKN YEIKNEADRT LIYITLYISE CLKKLQKCNS KSQGEKEMYT LGITNFPIPG EPGFPLNAIY AKPANKQEDE VMRAYLQQLR QETGLRLCEK VFDPQNDKPS KWWTCFVKRQ FMNKSLSGPG Q

Actin-related protein 2/3 complex subunit 3 (ARPC3) which Belongs to the ARPC3 family is one of 7 subunits of the human Arp2/3 protein complex. The Arp2/3 complex is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. ARPC3 which is localized to the cytoplasm and cytoskeleton, interacts with p20-ARC and takes part in the structural integrity of the protein complex.

ARPC3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 201 amino acids (1-178 a.a) and having a molecular mass of 22.9kDa. ARPC3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ARPC3: one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: Arp2/3 protein complex; focal adhesion; membrane; lamellipodium; cytosol; actin cytoskeleton

Molecular Function:actin filament binding; protein binding; structural constituent of cytoskeleton

Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility

NCBI Summary:This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
UniProt Code:O15145
NCBI GenInfo Identifier:3121765
NCBI Gene ID:10094
NCBI Accession:O15145.3
UniProt Secondary Accession:O15145,O00554,
UniProt Related Accession:O15145
Molecular Weight:178
NCBI Full Name:Actin-related protein 2/3 complex subunit 3
NCBI Synonym Full Names:actin related protein 2/3 complex, subunit 3, 21kDa
NCBI Official Symbol:ARPC3��
NCBI Official Synonym Symbols:ARC21; p21-Arc��
NCBI Protein Information:actin-related protein 2/3 complex subunit 3; arp2/3 complex 21 kDa subunit; ARP2/3 protein complex subunit p21
UniProt Protein Name:Actin-related protein 2/3 complex subunit 3
UniProt Synonym Protein Names:Arp2/3 complex 21 kDa subunit; p21-ARC
Protein Family:Actin-related protein 2/3 complex
UniProt Gene Name:ARPC3��
UniProt Entry Name:ARPC3_HUMAN
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