Human ARL4D Recombinant Protein (RPPB2791)

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SKU:
RPPB2791
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P49703

Description

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Product Name:Human ARL4D Recombinant Protein
Product Code:RPPB2791
Size:20µg
Species:Human
Target:ARL4D
Synonyms:ADP-ribosylation factor-like 4D, ADP-ribosylation factor-like protein 4L, ARF4L, ARL6.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ARL4D solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 0.2M NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGNHLTEMAP TASSFLPHFQ ALHVVVIGLD SAGKTSLLYR LKFKEFVQSV PTKGFNTEKI RVPLGGSRGI TFQVWDVGGQ EKLRPLWRSY TRRTDGLVFV VDAAEAERLE EAKVELHRIS RASDNQGVPV LVLANKQDQP GALSAAEVEK RLAVRELAAA TLTHVQGCSA VDGLGLQQGL ERLYEMILKR KKAARGGKKR R

ARL4D is a developmentally regulated member of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of Ras-related GTPases. Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). ARL4D takes part in membrane-associated intracellular trafficking. Mutations in this gene is linked to Bardet-Biedl syndrome (BBS).

ARL4D Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-201) and having a molecular mass of 24.3 kDa.ARL4D is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ARL4D: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. Belongs to the small GTPase superfamily. Arf family.
UniProt Protein Details:

Protein type:G protein; Nucleolus; G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: cytoplasm; nucleolus; plasma membrane

Molecular Function:GTPase activity; protein binding; GTP binding

Biological Process: metabolic process; small GTPase mediated signal transduction; protein secretion

NCBI Summary:ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). [provided by RefSeq, Jul 2008]
UniProt Code:P49703
NCBI GenInfo Identifier:41327767
NCBI Gene ID:379
NCBI Accession:NP_001652.2
UniProt Secondary Accession:P49703,B2RC59, D3DX43,
UniProt Related Accession:P49703
Molecular Weight:22,156 Da
NCBI Full Name:ADP-ribosylation factor-like protein 4D
NCBI Synonym Full Names:ADP-ribosylation factor-like 4D
NCBI Official Symbol:ARL4D��
NCBI Official Synonym Symbols:ARL6; ARF4L��
NCBI Protein Information:ADP-ribosylation factor-like protein 4D; ADP-ribosylation factor-like 6; ADP-ribosylation factor-like protein 4L
UniProt Protein Name:ADP-ribosylation factor-like protein 4D
UniProt Synonym Protein Names:ADP-ribosylation factor-like protein 4L
Protein Family:ADP-ribosylation factor-like protein
UniProt Gene Name:ARL4D��
UniProt Entry Name:ARL4D_HUMAN
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