Human ARL4A Recombinant Protein (RPPB2790)

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RPPB2790

Description

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Product Name:Human ARL4A Recombinant Protein
Product Code:RPPB2790
Size:10µg
Species:Human
Target:ARL4A
Synonyms:ADP-ribosylation factor-like protein 4A, ARL4A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ARL4A solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP TKGFNTEKIK VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV DSVDVERMEE AKTELHKITR ISENQGVPVL IVANKQDLRN SLSLSEIEKL LAMGELSSST PWHLQPTCAI IGDGLKEGLE KLHDMIIKRR KMLRQQKKKR

ARL4A is related Specifically to ARL6 and ARL7 and belongs to the ARF-like protein (ARL) subfamily of small GTPases. However, unlike ARFs, ARL4 does not activate the cholera toxin ADP-ribosyltranferase. ARL4A takes part in neurogenesis during embryonic development and somitogenesis in the early stages of adult spermatogenesis.

ARL4A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-200) and having a molecular mass of 24.7 kDa.The ARL4A is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:ARL4A: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. Belongs to the small GTPase superfamily. Arf family.
UniProt Protein Details:

Protein type:Nucleolus; G protein, monomeric; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: cytoplasm; plasma membrane; nucleolus; nucleus

Molecular Function:protein binding; GTP binding

Biological Process: small GTPase mediated signal transduction; brown fat cell differentiation

NCBI Summary:ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P40617
NCBI GenInfo Identifier:81295813
NCBI Gene ID:10124
NCBI Accession:NP_001032241
UniProt Secondary Accession:P40617,P80418, Q49AF5, A4D119,
UniProt Related Accession:P40617
Molecular Weight:22,615 Da
NCBI Full Name:ADP-ribosylation factor-like protein 4A
NCBI Synonym Full Names:ADP-ribosylation factor-like 4A
NCBI Official Symbol:ARL4A��
NCBI Official Synonym Symbols:ARL4��
NCBI Protein Information:ADP-ribosylation factor-like protein 4A
UniProt Protein Name:ADP-ribosylation factor-like protein 4A
UniProt Gene Name:ARL4A��
UniProt Entry Name:ARL4A_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P40617
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