Human ARL4A Recombinant Protein (RPPB2790)
- SKU:
- RPPB2790
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P40617
Description
| Product Name: | Human ARL4A Recombinant Protein |
| Product Code: | RPPB2790 |
| Size: | 10µg |
| Species: | Human |
| Target: | ARL4A |
| Synonyms: | ADP-ribosylation factor-like protein 4A, ARL4A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ARL4A solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP TKGFNTEKIK VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV DSVDVERMEE AKTELHKITR ISENQGVPVL IVANKQDLRN SLSLSEIEKL LAMGELSSST PWHLQPTCAI IGDGLKEGLE KLHDMIIKRR KMLRQQKKKR |
ARL4A is related Specifically to ARL6 and ARL7 and belongs to the ARF-like protein (ARL) subfamily of small GTPases. However, unlike ARFs, ARL4 does not activate the cholera toxin ADP-ribosyltranferase. ARL4A takes part in neurogenesis during embryonic development and somitogenesis in the early stages of adult spermatogenesis.
ARL4A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-200) and having a molecular mass of 24.7 kDa.The ARL4A is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ARL4A: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. Belongs to the small GTPase superfamily. Arf family. |
| UniProt Protein Details: | Protein type:Nucleolus; G protein, monomeric; G protein, monomeric, ARF Chromosomal Location of Human Ortholog: 7p21.3 Cellular Component: cytoplasm; plasma membrane; nucleolus; nucleus Molecular Function:protein binding; GTP binding Biological Process: small GTPase mediated signal transduction; brown fat cell differentiation |
| NCBI Summary: | ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P40617 |
| NCBI GenInfo Identifier: | 81295813 |
| NCBI Gene ID: | 10124 |
| NCBI Accession: | NP_001032241 |
| UniProt Secondary Accession: | P40617,P80418, Q49AF5, A4D119, |
| UniProt Related Accession: | P40617 |
| Molecular Weight: | 22,615 Da |
| NCBI Full Name: | ADP-ribosylation factor-like protein 4A |
| NCBI Synonym Full Names: | ADP-ribosylation factor-like 4A |
| NCBI Official Symbol: | ARL4A�� |
| NCBI Official Synonym Symbols: | ARL4�� |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 4A |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 4A |
| UniProt Gene Name: | ARL4A�� |
| UniProt Entry Name: | ARL4A_HUMAN |
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