Human ARF6 Recombinant Protein (RPPB2777)

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SKU:
RPPB2777
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62330

Description

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Product Name:Human ARF6 Recombinant Protein
Product Code:RPPB2777
Size:20µg
Species:Human
Target:ARF6
Synonyms:ADP-ribosylation factor 6, ARF6, DKFZp564M0264.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The ARF6 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 0.2mM PMSF and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE TVTYKNVKFN VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR QELHRIINDR EMRDAIILIF ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY VQPSCATSGD GLYEGLTWLT SNYKS

ARF6 is a part of the ADP ribosylation factor family of GTP-binding proteins. ARF6 is restricted to the plasma membrane, and controls vesicular trafficking, remodeling of membrane lipids, and signaling pathways which lead to actin remodeling. Furthermore, ARF6 is a key player in conservation of organelle integrity, assembly of coat proteins and activation of phospholipase D.

ARF6 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (1-175a.a.) and having a molecular mass of 22.2kDa.ARF6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762). Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1.
NCBI Summary:This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]
UniProt Code:P62330
NCBI GenInfo Identifier:51316984
NCBI Gene ID:382
NCBI Accession:P62330.2
UniProt Secondary Accession:P62330,P26438, Q6FGZ2,
UniProt Related Accession:P62330
Molecular Weight:20,082 Da
NCBI Full Name:ADP-ribosylation factor 6
NCBI Synonym Full Names:ADP ribosylation factor 6
NCBI Official Symbol:ARF6��
NCBI Protein Information:ADP-ribosylation factor 6
UniProt Protein Name:ADP-ribosylation factor 6
Protein Family:Auxin response factor
UniProt Gene Name:ARF6��
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