Human ARC Recombinant Protein (RPPB2770)

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SKU:
RPPB2770
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q7LC44

Description

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Product Name:Human ARC Recombinant Protein
Product Code:RPPB2770
Size:5µg
Species:Human
Target:ARC
Synonyms:Arg3.1, KIAA0278, Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, ARC.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ARC protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE

Activity-regulated cytoskeleton-associated protein (ARC) takes part in the regulation of cell morphology and cytoskeletal organization and is required for consolidation of synaptic plasticity as well as formation of long-term memory. ARC regulates endocytosis of AMPA receptors in response to synaptic activity and is also required for homeostatic synaptic scaling of AMPA receptors. ARC is required in the stress fiber dynamics and cell migration.

ARC Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 416 amino acids (1-396 a.a.) and having a molecular mass of 47.4kDa. ARC is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ARG3.1: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Belongs to the ARC/ARG3.1 family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: postsynaptic membrane; cytoplasm; postsynaptic density; plasma membrane; dendritic spine; acrosome; cell junction; endosome; actin cytoskeleton

Biological Process: anterior/posterior pattern formation; cell migration; regulation of cell morphogenesis; cytoskeleton organization and biogenesis; endocytosis; learning; endoderm development; regulation of neuronal synaptic plasticity

UniProt Code:Q7LC44
NCBI GenInfo Identifier:74738627
NCBI Gene ID:23237
NCBI Accession:Q7LC44.1
UniProt Secondary Accession:Q7LC44,Q9UJW6, Q9Y469,
UniProt Related Accession:Q7LC44
Molecular Weight:45,316 Da
NCBI Full Name:Activity-regulated cytoskeleton-associated protein
NCBI Synonym Full Names:activity-regulated cytoskeleton-associated protein
NCBI Official Symbol:ARC��
NCBI Official Synonym Symbols:Arg3.1��
NCBI Protein Information:activity-regulated cytoskeleton-associated protein; ARC/ARG3.1; ARC {ECO:0000312|EMBL:AAG33705.1}; activity-regulated gene 3.1 protein homolog
UniProt Protein Name:Activity-regulated cytoskeleton-associated protein
UniProt Synonym Protein Names:ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog; Arg3.1
Protein Family:Arcelin
UniProt Gene Name:ARC��
UniProt Entry Name:ARC_HUMAN
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