Human Arachidonate Lipoxygenase 5 / ALOX5 ELISA Kit

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SKU:
HUFI01242
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P09917
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
5-LO, Arachidonate 5-Lipoxygenase, ALOX5, 5LPG, LOG5, LOX5A, 5-lipoxygenase, 5-LOX, arachidonic 5-lipoxygenase alpha-10 isoform, arachidonic 5-lipoxygenase delta-10-13 isoform, arachidonic 5-lipoxygenase delta-13 isoform, arachidonic acid 5-lipoxygen
Reactivity:
Human
Research Area:
Metabolism

Description

Human Arachidonate Lipoxygenase 5 / ALOX5 ELISA Kit

Arachidonate Lipoxygenase 5/ALOX5 encodes a lipoxygenase enzyme, which has two functions in the formation of leukotrienes from arachidonic acid. The encoded protein, which is only produced in bone marrow-derived cells, converts arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid and subsequently to leukotriene A4. Leukotrienes are signaling molecules that participate in the inflammatory and allergic responses. Arachidonate Lipoxygenase 5/ALOX5 promoter region contains several mutations, one of which causes a reduced response to anti leukotriene medications used to treat asthma and might be connected with atherosclerosis and several malignancies. ALOX5 is associated with asthma and exercise-induced bronchoconstriction. Pathways associated with Arachidonate Lipoxygenase 5/ALOX5 include Arachidonic acid metabolism and Cytokine Signaling in the Immune System.

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