Cytokines Recombinant Proteins

Human APOM Recombinant Protein (RPPB0062)

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SKU:
RPPB0062
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95445
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human APOM Recombinant Protein
Product Code:RPPB0062
Size:10µg
Species:Human
Target:APOM
Synonyms:G3a, HSPC336, NG20, Apolipoprotein M, APOM, Apo-M, MGC22400.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:APOM Human solution containing 20mM Tris-HCl pH-8 1mM DTT & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MCPEHSQLTT LGVDGKEFPE VHLGQWYFIA GAAPTKEELA TFDPVDNIVF NMAAGSAPMQ LHLRATIRMK DGLCVPRKWI YHLTEGSTDL RTEGRPDMKT ELFSSSCPGG IMLNETGQGY QRFLLYNRSP HPPEKCVEEF KSLTSCLDSK AFLLTPRNQE ACELSNN

APOM is belongs to the lipocalin protein family and is associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. APOM is secreted through the plasma membrane but remains membrane-bound, where it takes part in lipid transport. .

APOM Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 187 amino acids (23-188 a.a.) and having a molecular mass of 20.9 kDa. APOM protein is fused to a 21 amino acid His-Tag at N-terminus and purified by standard chromatography.

UniProt Protein Function:APOM: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. Plasma protein. Expressed in liver and kidney. Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p21.33

Cellular Component: integral to plasma membrane

Molecular Function:antioxidant activity; lipid transporter activity; phospholipid binding

Biological Process: cholesterol homeostasis; reverse cholesterol transport; response to glucose stimulus; cholesterol efflux; lipoprotein metabolic process

NCBI Summary:The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]
UniProt Code:O95445
NCBI GenInfo Identifier:17370872
NCBI Gene ID:55937
NCBI Accession:O95445.2
UniProt Secondary Accession:O95445,Q5SRP4, Q9P046, Q9UMP6, B0UX98,
UniProt Related Accession:O95445
Molecular Weight:188
NCBI Full Name:Apolipoprotein M
NCBI Synonym Full Names:apolipoprotein M
NCBI Official Symbol:APOM��
NCBI Official Synonym Symbols:G3a; NG20; apo-M; HSPC336��
NCBI Protein Information:apolipoprotein M; protein G3a; NG20-like protein; alternative name: G3a, NG20
UniProt Protein Name:Apolipoprotein M
UniProt Synonym Protein Names:Protein G3a
Protein Family:Apomucin
UniProt Gene Name:APOM��
UniProt Entry Name:APOM_HUMAN
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