Cytokines Recombinant Proteins

Human APOH Recombinant Protein (RPPB2963)

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SKU:
RPPB2963
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P02749
Research Area:
Cytokines

Description

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Product Name:Human APOH Recombinant Protein
Product Code:RPPB2963
Size:1mg
Species:Human
Target:APOH
Synonyms:Beta-2-glycoprotein 1, Beta-2-glycoprotein I, Apolipoprotein H, Apo-H, B2GPI, Beta(2)GPI, Activated protein C-binding protein, APC inhibitor, Anticardiolipin cofactor, APOH, B2G1, BG, B2GP-1, B2 Glycoprotein-I.
Source:Human Plasma
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from 0.02M NH4HCO3.
Solubility:It is recommended to reconstitute the lyophilized APOH in phosphate buffer, pH >7.0 containing 0.15M NaCl.
Stability:Human APOH although stable at room temperature for 3 weeks, should be stored between 2-8°C.
Purity:Greater than 96.0%.

Apolipoprotein H (APOH) attaches to numerous kinds of negatively charged substances for instance heparin, phospholipids, and dextran sulfate. APOH prevents activation of the intrinsic blood coagulation cascade by attaching to phospholipids on the surface of damaged cells. APOH expressed by the liver and secreted in the plasma.

Human APOH produced in Human Plasma having a molecular mass of 50kDa and pI of 5.6-6.4. It�s a major phospholipid binding protein and an important component to measure in the assessment of anti-phospholipid syndrome. APOH is also more specific than anti-cardiolipin antibodies and its presence correlates better with thrombotic risk.

UniProt Protein Function:APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
UniProt Protein Details:

Protein type:Secreted; Lipid-binding; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface

Molecular Function:heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding

Biological Process: negative regulation of angiogenesis; negative regulation of myeloid cell apoptosis; triacylglycerol metabolic process; positive regulation of blood coagulation; negative regulation of fibrinolysis; negative regulation of endothelial cell proliferation; positive regulation of lipoprotein lipase activity; negative regulation of blood coagulation; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis

NCBI Summary:Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
UniProt Code:P02749
NCBI GenInfo Identifier:543826
NCBI Gene ID:350
NCBI Accession:P02749.3
UniProt Secondary Accession:P02749,Q9UCN7, B2R9M3,
UniProt Related Accession:P02749
Molecular Weight:345
NCBI Full Name:Beta-2-glycoprotein 1
NCBI Synonym Full Names:apolipoprotein H (beta-2-glycoprotein I)
NCBI Official Symbol:APOH��
NCBI Official Synonym Symbols:BG; B2G1; B2GP1��
NCBI Protein Information:beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein
UniProt Protein Name:Beta-2-glycoprotein 1
UniProt Synonym Protein Names:APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI
Protein Family:Beta-2-glycoprotein
UniProt Gene Name:APOH��
UniProt Entry Name:APOH_HUMAN
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