Epigenetics & Nuclear Signaling Recombinant Proteins
Human APE1/APE Recombinant Protein (RPES2965)
- SKU:
- RPES2965
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Epigenetics & Nuclear Signaling
Description
Human APE1/APE Recombinant Protein
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the damaged bases in your DNA are removed by the DNA glycosylase; APE1 cuts the AP site to allow resynthesis and ligation to finish the repair. APE1 stimulates the DNA binding activity of many transcription factors; which participate in cancer promotion and progression. APE1 controls the redox status of several transcription factors, such as c-Jun; c-Fos; NF-kB; and p53. APEN is also involved in calcium-dependent down-regulation of PTH expression. Human APE1/APE Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human APE1/APE Recombinant Protein (RPES2965) |
| Product Code: | RPES2965 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-Apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1REF-1, Redox Factor-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1 |
| Accession: | P27695 |
| Sequence: | Pro2-Leu318 |
| Fusion tag: | |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 35.6 kDa |
| AP Mol Mass: | 40 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 10mM HEPES; 100mM KCl; 50% Glycerol; pH 7.4. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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