Human ANXA3 Recombinant Protein (RPPB2753)

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RPPB2753

Description

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Product Name:Human ANXA3 Recombinant Protein
Product Code:RPPB2753
Size:20µg
Species:Human
Target:ANXA3
Synonyms:ANX3, ANXA3, Annexin-III, Lipocortin-3, Lipocortin-III, Annexin-3, Annexin A3, Placental anticoagulant protein III, PAP-III, 35-alpha calcimedin, Inositol 1,2-cyclic phosphate 2-phosphohydrolase.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The ANXA3 protein solution contains 20mM Tris-HCl, pH-7.5, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN AQRQLIVKEY QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK KSMKGAGTNE DALIEILTTR TSRQMKDISQ AYYTVYKKSL GDDISSETSG DFRKALLTLA DGRRDESLKV DEHLAKQDAQ ILYKAGENRW GTDEDKFTEI LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL LAIVNCVRNT PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY SAIKSDTSGD YEITLLKICG GDD

ANXA3 is an inhibitor of phospholipase A2. ANXA3 possesses anti-coagulant properties. ANXA3 cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. ANXA3 is part of the annexin family which are members of the calcium-dependent phospholipid-binding protein family that are involved in the regulation of cellular growth and in signal transduction pathways. ANXA3 takes part as an anti-coagulation factor.

ANXA3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 323 amino acids (1-323 a.a.) and having a molecular mass of 36.3 kDa.ANXA3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:ANXA3: a calcium/phospholipid-binding protein and inhibitor of phospholipase A2, Possesses anti-coagulant properties. Cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
UniProt Protein Details:

Protein type:Calcium-binding

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: cytoplasm; membrane; phagocytic vesicle membrane; plasma membrane; specific granule

Molecular Function:calcium-dependent phospholipid binding; calcium-dependent protein binding

Biological Process: defense response to bacterium; neutrophil degranulation; phagocytosis; positive regulation of angiogenesis; positive regulation of transcription factor activity

NCBI Summary:This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
UniProt Code:P12429
NCBI GenInfo Identifier:113954
NCBI Gene ID:306
NCBI Accession:P12429.3
UniProt Secondary Accession:P12429,Q6LET2, B2R9W6,
UniProt Related Accession:P12429
Molecular Weight:36,375 Da
NCBI Full Name:Annexin A3
NCBI Synonym Full Names:annexin A3
NCBI Official Symbol:ANXA3��
NCBI Official Synonym Symbols:ANX3��
NCBI Protein Information:annexin A3
UniProt Protein Name:Annexin A3
UniProt Synonym Protein Names:35-alpha calcimedin; Annexin III; Annexin-3; Inositol 1,2-cyclic phosphate 2-phosphohydrolase; Lipocortin III; Placental anticoagulant protein III; PAP-III
Protein Family:Annexin
UniProt Gene Name:ANXA3��
UniProt Entry Name:ANXA3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P12429
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