Cytokines Recombinant Proteins

Human ANGPTL3 (17-460) Recombinant Protein (RPPB0039)

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SKU:
RPPB0039
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y5C1
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human ANGPTL3 (17-460) Recombinant Protein
Product Code:RPPB0039
Size:10µg
Species:Human
Target:ANGPTL3 (17-460)
Synonyms:Angiopoietin Like 3, Angiopoietin 5, ANGPT5, ANG-5,Angiopoietin-Related Protein 3 , Angiopoietin-Like Protein 3, Angiopoietin-Like3, Angiopoietin-5, FHBL2, ANL3.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ANGPTL3 protein solution (0.25mg/ml) contains Buffered Saline (pH 7.4),30% glycerol And 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPSRIDQDN SSFDSLSPEP KSRFAMLDDV KILANGLLQL GHGLKDFVHKTKGQINDIFQ KLNIFDQSFY DLSLQTSEIK EEEKELRRTT YKLQVKNEEV KNMSLELNSK LESLLEEKIL LQQKVKYLEEQLTNLIQNQP ETPEHPEVTS LKTFVEKQDN SIKDLLQTVE DQYKQLNQQH SQIKEIENQL RRTSIQEPTEISLSSKPRAP RTTPFLQLNE IRNVKHDGIP AECTTIYNRG EHTSGMYAIR PSNSQVFHVY CDVISGSPWT LIQHRIDGSQNFNETWENYK YGFGRLDGEF WLGLEKIYSI VKQSNYVLRI ELEDWKDNKH YIEYSFYLGN HETNYTLHLVAITGNVPNAI PENKDLVFST WDHKAKGHFN CPEGYSGGWW WHDECGENNL NGKYNKPRAK SKPERRRGLS WKSQNGRLYSIKSTKMLIHP TDSESFEHHH HHH

ANGPTL3 and ANGPTL4 are angiopoietin-like proteins secreted and expressed mainly by the liver, their role being the regulation of triglyceride metabolism by inhibiting the lipolysis of triglyceride-rich lipoproteins. During different nutritional states (feeding/fasting) the levels of the circulating triglycerides are regulated by Angptl3 and Angptl4 through differential inhibition of Lipoprotein lipase (LPL) as shown by the experimental data. The molecular structure of ANGPTL3 is similar to that of the angiopoietins (vascular endothelial growth factors). Deletion mutants of human Angiopoietin 5 were used in order to demonstrate that the N-terminal domain (fragment 17-207) and not the C-terminal fibrinogen-like domain (fragment 207-460) increased the plasma triglyceride levels in mice.

ANGPTL3 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) andhaving a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE underreducing conditions).�ANGPTL3 is expressed with an 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.
UniProt Protein Details:

Protein type:Secreted; Cell adhesion; Inhibitor; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: extracellular space; cell surface

Molecular Function:integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity

Biological Process: integrin-mediated signaling pathway; cholesterol metabolic process; phospholipid catabolic process; glycerol metabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; fatty acid metabolic process; signal transduction; sequestering of lipid; positive regulation of angiogenesis; cholesterol homeostasis; acylglycerol homeostasis; phospholipid metabolic process; artery morphogenesis; negative regulation of lipoprotein lipase activity; positive regulation of cell migration; phospholipid homeostasis

Disease: Hypobetalipoproteinemia, Familial, 2

NCBI Summary:This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]
UniProt Code:Q9Y5C1
NCBI GenInfo Identifier:25008126
NCBI Gene ID:27329
NCBI Accession:Q9Y5C1.1
UniProt Related Accession:Q9Y5C1
Molecular Weight:~ 54kDa
NCBI Full Name:Angiopoietin-related protein 3
NCBI Synonym Full Names:angiopoietin like 3
NCBI Official Symbol:ANGPTL3��
NCBI Official Synonym Symbols:ANL3; ANG-5; FHBL2; ANGPT5��
NCBI Protein Information:angiopoietin-related protein 3
UniProt Protein Name:Angiopoietin-related protein 3
UniProt Synonym Protein Names:Angiopoietin-5; ANG-5; Angiopoietin-like protein 3
Protein Family:Angiopoietin-related protein
UniProt Gene Name:ANGPTL3��
UniProt Entry Name:ANGL3_HUMAN
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