Human ANAPC13 Recombinant Protein (RPPB2735)
- SKU:
- RPPB2735
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BS18
Description
| Product Name: | Human ANAPC13 Recombinant Protein |
| Product Code: | RPPB2735 |
| Size: | 10µg |
| Species: | Human |
| Target: | ANAPC13 |
| Synonyms: | Anaphase-promoting complex subunit 13, APC13, Cylosome subunit 13, ANAPC13, SWM1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The ANAPC13 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 1mM DTT and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MASMTGGQQM GRGSHMDSEV QRDGRILDLI DDAWREDKLP YEDVAIPLNE LPEPEQDNGG TTESVKEQEM KWTDLALQYL HENVPPIGN |
Anaphase-promoting complex subunit 13 (ANAPC13) is a component of the anaphase promoting complex, which is a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The ANAPC13 protein is evolutionarily conserved and is essential for the integrity and ubiquitin ligase activity of the anaphase promoting complex.
ANAPC13 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 89 amino acids (1-74) and having a molecular mass of 10kDa (Molecular weight on SDS-PAGE will appear higher).ANAPC13 protein is fused to a 15 amino acid T7-tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | APC13: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC13 family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 3q22.2 Cellular Component: anaphase-promoting complex Biological Process: mitosis; cell division |
| NCBI Summary: | This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q9BS18 |
| NCBI GenInfo Identifier: | 74732956 |
| NCBI Gene ID: | 25847 |
| NCBI Accession: | Q9BS18.1 |
| UniProt Secondary Accession: | Q9BS18,Q9Y3V0, |
| UniProt Related Accession: | Q9BS18 |
| Molecular Weight: | 8,521 Da |
| NCBI Full Name: | Anaphase-promoting complex subunit 13 |
| NCBI Synonym Full Names: | anaphase promoting complex subunit 13 |
| NCBI Official Symbol: | ANAPC13�� |
| NCBI Official Synonym Symbols: | SWM1; APC13�� |
| NCBI Protein Information: | anaphase-promoting complex subunit 13; cyclosome subunit 13 |
| UniProt Protein Name: | Anaphase-promoting complex subunit 13 |
| UniProt Synonym Protein Names: | Cyclosome subunit 13 |
| UniProt Gene Name: | ANAPC13�� |
| UniProt Entry Name: | APC13_HUMAN |
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