Human AMELX Recombinant Protein (RPPB2729)
- SKU:
- RPPB2729
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q99217
Description
| Product Name: | Human AMELX Recombinant Protein |
| Product Code: | RPPB2729 |
| Size: | 10µg |
| Species: | Human |
| Target: | AMELX |
| Synonyms: | Amelogenin X isoform, AMELX, AMG, AMGX, AI1E, AIH1, ALGN, AMGL. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | AMELX protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.5), 0.2M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPLPPHP GHPGYINFSY EVLTPLKWYQ SIRPPYPSYG YEPMGGWLHH QIIPVLSQQH PPTHTLQPHH HIPVVPAQQP VIPQQPMMPV PGQHSMTPIQ HHQPNLPPPA QQPYQPQPVQ PQPHQPMQPQ PPVHPMQPLP PQPPLPPMFP MQPLPPMLPD LTLEAWPSTD KTKREEVD |
Amelogenin, X-Linked (AMELX) belongs to the amelogenin family of extracellular matrix proteins. Amelogenins have a role biomineralization during tooth enamel development. AMELX gene mutations cause X-linked amelogenesis imperfecta. AMELX regulates the formation of crystallites during the secretory stage of tooth enamel development. AMELX is transiently but amply expressed by ameloblasts during tooth development. Amelogenin is the principal protein in developing dental enamel.
AMELX Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (17-191 a.a) and having a molecular mass of 22kDa.AMELX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AMELX: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Defects in AMELX are the cause of amelogenesis imperfecta type 1E (AI1E). A X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small. Belongs to the amelogenin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xp22.31-p22.1 Cellular Component: cell surface; proteinaceous extracellular matrix Molecular Function:growth factor activity; hydroxyapatite binding; identical protein binding; protein binding; structural constituent of tooth enamel Biological Process: biomineral formation; cell adhesion; cell proliferation; chondrocyte differentiation; epithelial to mesenchymal transition; ion homeostasis; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of collagen biosynthetic process; signal transduction Disease: Amelogenesis Imperfecta, Type Ie |
| NCBI Summary: | This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99217 |
| NCBI GenInfo Identifier: | 1168430 |
| NCBI Gene ID: | 265 |
| NCBI Accession: | Q99217.1 |
| UniProt Secondary Accession: | Q99217,Q96NW6, Q9UCA7, |
| UniProt Related Accession: | Q99217 |
| Molecular Weight: | 23,111 Da |
| NCBI Full Name: | Amelogenin, X isoform |
| NCBI Synonym Full Names: | amelogenin, X-linked |
| NCBI Official Symbol: | AMELX�� |
| NCBI Official Synonym Symbols: | AMG; AI1E; AIH1; ALGN; AMGL; AMGX�� |
| NCBI Protein Information: | amelogenin, X isoform |
| UniProt Protein Name: | Amelogenin, X isoform |
| Protein Family: | Amelogenin |
| UniProt Gene Name: | AMELX�� |
| UniProt Entry Name: | AMELX_HUMAN |
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