Cytokines Recombinant Proteins

Human AIMP1 Recombinant Protein (RPPB5726)

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SKU:
RPPB5726
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q12904
Research Area:
Cytokines

Description

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Product Name:Human AIMP1 Recombinant Protein
Product Code:RPPB5726
Size:5µg
Species:Human
Target:AIMP1
Synonyms:Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, AIMP1, EMAP2, SCYE1, p43, EMAPII.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The AIMP1 solution (0.25mg/ml) 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 2mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MLPAVAVSEP VVLRFMIFCR LLAKMANNDA VLKRLEQKGA EADQIIEYLK QQVSLLKEKA ILQATLREEK KLRVENAKLK KEIEELKQEL IQAEIQNGVK QIPFPSGTPL HANSMVSENV IQSTAVTTVS SGTKEQIKGG TGDEKKAKEK IEKKGEKKEK KQQSIAGSAD SKPIDVSRLD LRIGCIITAR KHPDADSLYV EEVDVGEIAP RTVVSGLVNH VPLEQMQNRM VILLCNLKPA KMRGVLSQAM VMCASSPEKI EILAPPNGSV PGDRITFDAF PGEPDKELNP KKKIWEQIQP DLHTNDECVA TYKGVPFEVK GKGVCRAQTM SNSGIK

AIMP1 (EMPA2 or p43) is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of the AIMP1 cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore, AIMP1 is involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells.

AIMP1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 356 amino acids (1-336 a.a.) and having a molecular mass of 39.2kDa (Molecular size on SDS-PAGE will appear higher). The AIMP1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
NCBI Summary:The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
UniProt Code:Q12904
NCBI GenInfo Identifier:85700432
NCBI Gene ID:9255
NCBI Accession:Q12904.2
UniProt Secondary Accession:Q12904,Q6FG28, Q96CQ9, B3KTR2, B4E1S7,
UniProt Related Accession:Q12904
Molecular Weight:37,039 Da
NCBI Full Name:Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
NCBI Synonym Full Names:aminoacyl tRNA synthetase complex interacting multifunctional protein 1
NCBI Official Symbol:AIMP1��
NCBI Official Synonym Symbols:p43; HLD3; EMAP2; SCYE1; EMAPII��
NCBI Protein Information:aminoacyl tRNA synthase complex-interacting multifunctional protein 1
UniProt Protein Name:Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
UniProt Synonym Protein Names:Multisynthase complex auxiliary component p43
Protein Family:Aminoacyl tRNA synthase complex-interacting multifunctional protein
UniProt Gene Name:AIMP1��
UniProt Entry Name:AIMP1_HUMAN
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