Human AgRP/AGRP Recombinant Protein (RPES2346)

(No reviews yet) Write a Review
SKU:
RPES2346
Product Type:
Recombinant Protein
Species:
Human

Description

system_update_altDatasheet

Human AgRP/AGRP Recombinant Protein

Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

View AllClose

0 Reviews

View AllClose