Human AgRP/AGRP Recombinant Protein (RPES2346)
- SKU:
- RPES2346
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Human AgRP/AGRP Recombinant Protein
Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
| Product Name: | Human AgRP/AGRP Recombinant Protein (RPES2346) |
| Product Code: | RPES2346 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | AGRT,ART,ASIP2 |
| Accession: | NP_001129.1 |
| Sequence: | Met 1-Thr 132 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed,with a polyhistidine tag at the C-terminus. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 14 kDa |
| AP Mol Mass: | 16-19 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.2 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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