Natural Proteins Recombinant Proteins

Human AFP Recombinant Protein (RPPB2828)

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SKU:
RPPB2828
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P02771
Research Area:
Natural Proteins

Description

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Product Name:Human AFP Recombinant Protein
Product Code:RPPB2828
Size:50µg
Species:Human
Target:AFP
Synonyms:Alpha-fetoprotein, Alpha-fetoglobulin, Alpha-1-fetoprotein, AFP, FETA, HPAFP.
Source:Human cord serum
Physical Appearance:Sterile Filtered clear solution.
Formulation:AFP protein filtered (0.2�m) solution in Tris buffered saline pH 7.5 and less than 0.1% NaN3.
Stability:Human Alpha-Fetoprotein should be stored at 2-8°C.

AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.

Human alpha-fetoprotein purified from pooled human cord serum.

UniProt Protein Function:AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; cytoplasm

Molecular Function:metal ion binding

Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle

Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of

NCBI Summary:This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
UniProt Code:P02771
NCBI GenInfo Identifier:120042
NCBI Gene ID:174
NCBI Accession:P02771.1
UniProt Secondary Accession:P02771,B2RBU3,
UniProt Related Accession:P02771
Molecular Weight:609
NCBI Full Name:Alpha-fetoprotein
NCBI Synonym Full Names:alpha-fetoprotein
NCBI Official Symbol:AFP��
NCBI Official Synonym Symbols:AFPD; FETA; HPAFP��
NCBI Protein Information:alpha-fetoprotein; alpha-fetoglobulin; alpha-1-fetoprotein
UniProt Protein Name:Alpha-fetoprotein
UniProt Synonym Protein Names:Alpha-1-fetoprotein; Alpha-fetoglobulin
Protein Family:AFP
UniProt Gene Name:AFP��
UniProt Entry Name:FETA_HUMAN
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