Human AFAP1 Recombinant Protein (RPPB2708)
- SKU:
- RPPB2708
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8N556
Description
| Product Name: | Human AFAP1 Recombinant Protein |
| Product Code: | RPPB2708 |
| Size: | 10µg |
| Species: | Human |
| Target: | AFAP1 |
| Synonyms: | Actin filament-associated protein 1, 110 kDa actin filament-associated protein, AFAP-110, AFAP1, AFAP, Actin Filament Associated Protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The AFAP1 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGCSGPVDSE CPPPPSSPVH KAELEKKLSS ERPSSDGEGV VENGITTCNG KEQVKRKKSS KSEAKGTVSK VTGKKITKII SLGKKKPSTD EQTSSAEEDV PTCGYLNVLS NSRWRERWCR VKDNKLIFHK DRTDLKTHIV SIPLRGCEVI PGLDCKHPLT FRLLRNGQEV AVLEASSSED MGRWIGILLA ETGSSTDPEA LHYDYIDVEM SASVIQTAKQ TFCFMNRRVI SANPYLGGTS NGYAHPSGTA LHYDDVPCIN GSLRGKKPPV ASNGVTGKGK TLSSQPKKAD PAAVVKRTGS NAAQYKYGKN RVEADAKRLQ TKEEELLKRK EALRNRLAQL |
Actin Filament Associated Protein 1 (AFAP1) is a Src binding partner. AFAP1 is a possible modulator of actin filament integrity in response to cellular signals, and is also playing a role as an adaptor protein by connecting Src family members to actin filaments. AFAP1 takes partin the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
AFAP1 Human Recombinant produced in E. coli is a single polypeptide chain containing 360 amino acids (250-588) and having a molecular mass of 39.2 kDa.AFAP1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | AFAP: Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 4p16 Cellular Component: focal adhesion; cytoplasm; actin cytoskeleton Molecular Function:actin binding Biological Process: regulation of signal transduction; regulation of cytoskeleton organization and biogenesis |
| NCBI Summary: | The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q8N556 |
| NCBI GenInfo Identifier: | 166919564 |
| NCBI Gene ID: | 60312 |
| NCBI Accession: | Q8N556.2 |
| UniProt Secondary Accession: | Q8N556,Q59EY5, Q9HBY1, A8K442, B4DMU2, E9PDT7, |
| UniProt Related Accession: | Q8N556 |
| Molecular Weight: | 730 |
| NCBI Full Name: | Actin filament-associated protein 1 |
| NCBI Synonym Full Names: | actin filament associated protein 1 |
| NCBI Official Symbol: | AFAP1�� |
| NCBI Official Synonym Symbols: | AFAP; AFAP110; AFAP-110�� |
| NCBI Protein Information: | actin filament-associated protein 1; 110 kDa actin filament-associated protein; actin filament-associated protein, 110 kDa |
| UniProt Protein Name: | Actin filament-associated protein 1 |
| UniProt Synonym Protein Names: | 110 kDa actin filament-associated protein; AFAP-110 |
| Protein Family: | Actin filament-associated protein |
| UniProt Gene Name: | AFAP1�� |
| UniProt Entry Name: | AFAP1_HUMAN |
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