Human ADAM12 Recombinant Protein (RPPB2702)
- SKU:
- RPPB2702
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O43184
Description
| Product Name: | Human ADAM12 Recombinant Protein |
| Product Code: | RPPB2702 |
| Size: | 10µg |
| Species: | Human |
| Target: | ADAM12 |
| Synonyms: | Meltrin alpha, MCMP, MLTN, MLTNA, MCMPMltna, ADAM metallopeptidase domain 12, ADAM 12, ADAM12. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ADAM12 solution contains�25mM Sodium Acetate pH 4.8 and 50% Glycerol.� |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
ADAM12 is part of the A Disintegrin and Metalloprotease protein family wjich are membrane-anchored proteins structurally related to snake venom disintegrins, and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions, including fertilization, muscle development, and eurogenesis. ADAM12 has 2 alternatively spliced transcripts, a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta, embryo and foetus although levels have been detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration, specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (by similarity).
ADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 531 amino acids (208-738) and having a molecular mass of 62 kDa.
| UniProt Protein Function: | ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis. |
| UniProt Protein Details: | Protein type:Protease; Membrane protein, integral; EC 3.4.24.-; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q26 Cellular Component: nucleoplasm; mitochondrion; integral to membrane; plasma membrane; extracellular region Molecular Function:protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; SH3 domain binding Biological Process: epidermal growth factor receptor signaling pathway; proteolysis; cell adhesion; myoblast fusion |
| NCBI Summary: | This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014] |
| UniProt Code: | O43184 |
| NCBI GenInfo Identifier: | 229463008 |
| NCBI Gene ID: | 8038 |
| NCBI Accession: | O43184.3 |
| UniProt Secondary Accession: | O43184,O60470, Q5JRP0, Q5JRP1, Q6P9E3, Q6UWB0, |
| UniProt Related Accession: | O43184 |
| Molecular Weight: | 909 |
| NCBI Full Name: | Disintegrin and metalloproteinase domain-containing protein 12 |
| NCBI Synonym Full Names: | ADAM metallopeptidase domain 12 |
| NCBI Official Symbol: | ADAM12�� |
| NCBI Official Synonym Symbols: | MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1�� |
| NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane |
| UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 12 |
| UniProt Synonym Protein Names: | Meltrin-alpha |
| Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
| UniProt Gene Name: | ADAM12�� |
| UniProt Entry Name: | ADA12_HUMAN |
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