Enzymes Recombinant Proteins

Human ACY3 Recombinant Protein (RPPB5785)

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SKU:
RPPB5785
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96HD9
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human ACY3 Recombinant Protein
Product Code:RPPB5785
Size:10µg
Species:Human
Target:ACY3
Synonyms:Aspartoacylase-2, Acylase III, Aminoacylase-3, ACY-3, Hepatitis C virus core-binding protein 1, HCBP1, ACY3, ASPA2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:ACY3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMCSLPVP REPLRRVAVT GGTHGNEMSG VYLARHWLHA PAELQRASFS AVPVLANPAA TSGCRRYVDHDLNRTFTSSF LNSRPTPDDP YEVTRARELN QLLGPKASGQ AFDFVLDLHN TTANMGTCLI AKSSHEVFAM HLCRHLQLQY PELSCQVFLY QRSGEESYNL DSVAKNGLGL ELGPQPQGVL RADIFSRMRT LVATVLDFIE LFNQGTAFPA FEMEAYRPVG VVDFPRTEAG HLAGTVHPQL QDRDFQPLQP GAPIFQMFSG EDLLYEGEST VYPVFINEAA YYEKGVAFVQ TEKFTFTVPA MPALTPAPSP AS

Aspartoacylase 3 (ACY3) belongs to the Aspartoacylase subfamily. ACY3 has a vital role in deacetylating mercapturic acids in kidney proximal tubules. Aspartoacylase 3 localizes to the cytoplasm of S2 and S3 proximal tubules and also to the apical domain of S1 proximal tubules. In addition, ACY3 protein is expressed at low levels in the stomach, testis, heart, brain, lung and liver, and can function as an HCV (Hepatitis C virus) core binding protein.

ACY3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 342 amino acids (1-319 a.a.) and having a molecular mass of 37.6kDa.ACY3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ACY3: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Belongs to the AspA/AstE family. Aspartoacylase subfamily.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - alanine, aspartate and glutamate; Hydrolase; EC 3.5.1.114; Amino Acid Metabolism - histidine

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytosol

Molecular Function:aminoacylase activity; protein binding

Biological Process: xenobiotic metabolic process

UniProt Code:Q96HD9
NCBI GenInfo Identifier:34395507
NCBI Gene ID:91703
NCBI Accession:Q96HD9.1
UniProt Related Accession:Q96HD9
Molecular Weight:35,241 Da
NCBI Full Name:N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
NCBI Synonym Full Names:aminoacylase 3
NCBI Official Symbol:ACY3��
NCBI Official Synonym Symbols:ACY-3; HCBP1��
NCBI Protein Information:N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
UniProt Protein Name:N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
UniProt Synonym Protein Names:Acylase III; Aminoacylase-3; ACY-3; Aspartoacylase-2; Hepatitis C virus core-binding protein 1; HCBP1; HCV core-binding protein 1
Protein Family:N-acyl-aromatic-L-amino acid amidohydrolase
UniProt Gene Name:ACY3��
UniProt Entry Name:ACY3_HUMAN
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system_update_altDatasheetHuman ACY3 Recombinant Protein Aspartoacylase 3, also known as ACY3, N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Acylase III, Aminoacylase-3, Aspa