Human ACTN1 Recombinant Protein (RPPB2727)
- SKU:
- RPPB2727
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P12814
Description
| Product Name: | Human ACTN1 Recombinant Protein |
| Product Code: | RPPB2727 |
| Size: | 20µg |
| Species: | Human |
| Target: | ACTN1 |
| Synonyms: | ACTN1, Actinin, Alpha 1, Alpha-Actinin CytoskeletalIsoform, F-Actin Cross-Linking Protein, Non-Muscle Alpha-Actinin-1, BDPLT15,Actinin 1 Smooth Muscle, Alpha-Actinin-1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ACTN1 protein solution (1mg/ml) containing PhosphateBuffered Saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSH MGSEFMDHYD SQQTNDYMQP EEDWDRDLLL DPAWEKQQRKTFTAWCNSHL RKAGTQIENI EEDFRDGLKL MLLLEVISGE RLAKPERGKM RVHKISNVNK ALDFIASKGVKLVSIGAEEI VDGNVKMTLG MIWTIILRFA IQDISVEETS AKEGLLLWCQ RKTAPYKNVN IQNFHISWKDGLGFCALIHR HRPELIDYGK LRKDDPLTNL NTAFDVAEKY LDIPKMLDAE DIVGTARPDE KAIMTYVSSF YHAF |
ACTN1 encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
ACTN1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 274 amino acids (1-249 a.a) andhaving a molecular mass of 31.4kDa. ACTN1 is fused to a 25 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 14q24|14q22-q24 Cellular Component: extracellular space; cortical actin cytoskeleton; focal adhesion; extracellular region; dendritic spine; fascia adherens; pseudopodium; cytosol; Z disc; ruffle; cell projection; cytoplasm; plasma membrane; stress fiber; nucleus Molecular Function:actin filament binding; integrin binding; protein domain specific binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; double-stranded RNA binding; calcium ion binding; vinculin binding Biological Process: regulation of apoptosis; actin crosslink formation; focal adhesion formation; platelet activation; actin filament bundle formation; extracellular matrix organization and biogenesis; platelet degranulation; negative regulation of cell motility; blood coagulation Disease: Bleeding Disorder, Platelet-type, 15 |
| NCBI Summary: | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12814 |
| NCBI GenInfo Identifier: | 46397817 |
| NCBI Gene ID: | 87 |
| NCBI Accession: | P12814.2 |
| UniProt Secondary Accession: | P12814,Q1HE25, Q9BTN1, B3V8S3, B4DHH3, B7TY16, |
| UniProt Related Accession: | P12814 |
| Molecular Weight: | 892 |
| NCBI Full Name: | Alpha-actinin-1 |
| NCBI Synonym Full Names: | actinin, alpha 1 |
| NCBI Official Symbol: | ACTN1�� |
| NCBI Official Synonym Symbols: | BDPLT15�� |
| NCBI Protein Information: | alpha-actinin-1; actinin 1 smooth muscle; non-muscle alpha-actinin-1; F-actin cross-linking protein; alpha-actinin cytoskeletal isoform |
| UniProt Protein Name: | Alpha-actinin-1 |
| UniProt Synonym Protein Names: | Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1 |
| Protein Family: | Alpha-actinin |
| UniProt Gene Name: | ACTN1�� |
| UniProt Entry Name: | ACTN1_HUMAN |
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