Human Activin RIIA/ACVR2A Recombinant Protein (RPES5020)

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SKU:
RPES5020
Product Type:
Recombinant Protein
Species:
Human

Description

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Human Activin RIIA/ACVR2A Recombinant Protein

ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.

Product Name:Human Activin RIIA/ACVR2A Recombinant Protein (RPES5020)
Product Code:RPES5020
Size:100µg
Species:Human
Expressed Host:HEK293 Cells
Synonyms:Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2,ACTRII
Accession:NP_001607.1
Sequence:Met 1-Pro 134
Fusion tag:C-His
Activity:Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 0.4-3 ¦Ìg/mL in the presence of 10 ng/mL recombinant Activin A
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the extracellular domain of human ACVR2A (NP_001607.1) (Met 1-Pro 134) was expressed, with a polyhistidine tag at the C-terminus.
Purity:> 97 % as determined by reducing SDS-PAGE.
Mol Mass:14.9 kDa
AP Mol Mass:35-40 kDa
Formulation:Lyophilized from sterile PBS, pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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