Growth Factors & Cytokines Recombinant Proteins

Human Activin A Recombinant Protein (RPPB0003)

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SKU:
RPPB0003
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P08476
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human Activin A Recombinant Protein
Product Code:RPPB0003
Size:10µg
Species:Human
Target:Activin A
Synonyms:Activin Beta-A chain, Erythroid differentiation protein, EDF, FRP, Activin-A, Inhibin-B, Inihibin-Beta A chain.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Activin-A protein solution (1mg/ml) contains 20mM Tris pH 8.0 and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS

Inhibins are dimeric peptide hormones produced by female ovarian granulose cells and male Sertoli cells as well as a variety of other tissues. Inhibins have two isoforms, A and B, with the same alpha subunit but different beta subunits. Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits.Inhibins are thought to inhibit the production of follicle-stimulating hormone (FSH) by the pituitary gland. In addition, Inhibins are also thought to play a role in the control of gametogenesis, and embryonic and fetal development.

Activin-A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 137 amino acids (311-426) and having a molecular mass of 15.2kDa.Activin-A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: extracellular region

Molecular Function:cytokine activity; growth factor activity; hormone activity; identical protein binding; peptide hormone binding; protein binding; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; cell cycle arrest; cell development; cell differentiation; cell surface receptor linked signal transduction; cell-cell signaling; defense response; G1/S transition of mitotic cell cycle; hair follicle development; hemoglobin biosynthetic process; hemopoietic progenitor cell differentiation; male gonad development; negative regulation of B cell differentiation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of interferon-gamma biosynthetic process; negative regulation of macrophage differentiation; negative regulation of phosphorylation; odontogenesis; ovarian follicle development; palate development; positive regulation of cellular protein metabolic process; positive regulation of erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; progesterone secretion; regulation of follicle-stimulating hormone secretion; regulation of MAPKKK cascade; regulation of transcription from RNA polymerase II promoter; response to drug; striatal medium spiny neuron differentiation

NCBI Summary:This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
UniProt Code:P08476
NCBI GenInfo Identifier:124279
NCBI Gene ID:3624
NCBI Accession:P08476.2
UniProt Secondary Accession:P08476,Q14599,
UniProt Related Accession:P08476
Molecular Weight:47,442 Da
NCBI Full Name:Inhibin beta A chain
NCBI Synonym Full Names:inhibin beta A subunit
NCBI Official Symbol:INHBA��
NCBI Official Synonym Symbols:EDF; FRP��
NCBI Protein Information:inhibin beta A chain
UniProt Protein Name:Inhibin beta A chain
UniProt Synonym Protein Names:Activin beta-A chain; Erythroid differentiation protein; EDF
Protein Family:Inhibin
UniProt Gene Name:INHBA��
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