Enzymes Recombinant Proteins

Human ACP6 Recombinant Protein (RPPB1340)

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RPPB1340

Description

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Product Name:Human ACP6 Recombinant Protein
Product Code:RPPB1340
Size:20µg
Species:Human
Target:ACP6
Synonyms:AcidPhosphatase 6, Lysophosphatidic, Acid Phosphatase-Like Protein 1, PACPL1,ACPL1, LPAP, Lysophosphatidic Acid Phosphatase Type 6, Lysophosphatidic AcidPhosphatase 6, Acid Phosphatase Like 1, EC 3.1.3.2, Lysophosphatidic acidphosphatase type 6.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:ACP6 protein solution (1mg/ml) containing Phosphatebuffered saline (pH7.4), 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSELQEADG QCPVDRSLLK LKMVQVVFRH GARSPLKPLP LEEQVEWNPQLLEVPPQTQF DYTVTNLAGG PKPYSPYDSQ YHETTLKGGM FAGQLTKVGM QQMFALGERL RKNYVEDIPFLSPTFNPQEV FIRSTNIFRN LESTRCLLAG LFQCQKEGPIIIHTDEADSE VLYPNYQSCW SLRQRTRGRR QTASLQPGIS EDLKKVKDRMGIDSSDKVDF FILLDNVAAE QAHNLPSCPM LKRFARMIEQ RAVDTSLYIL PKEDRESLQM AVGPFLHILESNLLKAMDSA TAPDKIRKLY LYAAHDVTFI PLLMTLGIFD HKWPPFAVDL TMELYQHLESKEWFVQLYYH GKEQVPRGCPDGLCPLDMFL NAMSVYTLSP EKYHALCSQT QVMEVGNEE
Biological Activity:Specific activity is > 70 units/mg, and is defined as the amount of enzyme which hydrolyze 1.0 nmoles of p-nitrophenyl phosphate (pNPP) per minute at PH�5.0 at 37C.

Acid Phosphatase-6, also known as ACP6 is Hydrolyzes lysophosphatidicacid (LPA) which contains a medium length fatty acid chain to the correspondingmonoacylglycerol. ACP6 shows highest activity with lysophosphatidic acid whichcontains myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0),and lower activity with C18:0 as well as C6:0 lysophosphatidic acid.

ACP6 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 419 amino acids (33-428a.a) andhaving a molecular mass of 47.7kDa.ACP6 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:ACP6: Hydrolyzes lysophosphatidic acid to monoacylglycerol. Belongs to the histidine acid phosphatase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Mitochondrial; EC 3.1.3.2; Secreted; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - riboflavin

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; mitochondrion

Biological Process: phospholipid metabolic process

NCBI Summary:This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]
UniProt Code:Q9NPH0
NCBI GenInfo Identifier:317373268
NCBI Gene ID:51205
NCBI Accession:Q9NPH0.2
UniProt Secondary Accession:Q9NPH0,Q59G61, Q5T490, Q6IAQ3, Q7LG81, Q9UIG6,
UniProt Related Accession:Q9NPH0
Molecular Weight:30,790 Da
NCBI Full Name:Lysophosphatidic acid phosphatase type 6
NCBI Synonym Full Names:acid phosphatase 6, lysophosphatidic
NCBI Official Symbol:ACP6��
NCBI Official Synonym Symbols:LPAP; ACPL1; PACPL1��
NCBI Protein Information:lysophosphatidic acid phosphatase type 6
UniProt Protein Name:Lysophosphatidic acid phosphatase type 6
UniProt Synonym Protein Names:Acid phosphatase 6, lysophosphatidic; Acid phosphatase-like protein 1; PACPL1
Protein Family:Lysophosphatidic acid phosphatase
UniProt Gene Name:ACP6��
UniProt Entry Name:PPA6_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NPH0
Research Area:
Enzymes
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