Enzymes Recombinant Proteins

Human ACOT11 Recombinant Protein (RPPB5776)

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SKU:
RPPB5776
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WXI4
Research Area:
Enzymes

Description

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Product Name:Human ACOT11 Recombinant Protein
Product Code:RPPB5776
Size:20µg
Species:Human
Target:ACOT11
Synonyms:Acyl-CoA Thioesterase 11, StAR-Related Lipid Transfer (START) Domain Containing 14, Thioesterase, Adipose Associated, Acyl-CoA Thioester Hydrolase 11, Adipose-Associated Thioesterase, Brown Fat-Inducible Thioesterase, Thioesterase Superfamily Member 1, START Domain Containing 14, Acyl-Coenzyme A Thioesterase 11, STARD14, THEM1, THEA, BFIT, BFIT1, BFIT2, KIAA0707, EC 3.1.2.1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ACOT11 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSNRTS RKSALRAGND SAMADGEGYR NPTEVQMSQL VLPCHTNQRG ELSVGQLLKW IDTTACLSAE RHAGCPCVTA SMDDIYFEHT ISVGQVVNIK AKVNRAFNSS MEVGIQVASE DLCSEKQWNV CKALATFVAR REITKVKLKQ ITPRTEEEKM EHSVAAERRR MRLVYADTIK DLLANCAIQG DLESRDCSRM VPAEKTRVES VELVLPPHAN HQGNTFGGQI MAWMENVA

ACOT11 belongs to the acyl-CoA thioesterase family which catalyses the transformation of activated fatty acids to the equivalent non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and inhibited by high temperatures. Obesity-resistant mice demonstrated High levels of expression compared with obesity-prone mice, indicating BFIT takes part in acyl-CoA thioesterase 11 in obesity. BFIT has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.

ACOT11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain topological domain containing 268 amino acids (19-250 a.a) and having a molecular mass of 29.9kDa. ACOT11 is fused to a 36 amino acid His-tag at N-terminus.

UniProt Protein Function:ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.2.-Chromosomal Location of Human Ortholog: 1p32.3Cellular Component: cytoplasmMolecular Function: acyl-CoA hydrolase activity; lipid bindingBiological Process: response to temperature stimulus; response to cold; fatty acid metabolic process
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
UniProt Code:Q8WXI4
NCBI GenInfo Identifier:21363000
NCBI Gene ID:26027
NCBI Accession:Q8WXI4.1
UniProt Secondary Accession:Q8WXI4,O75187, Q52LP1, Q53ER9, Q96DI1, Q9H883, B1AQ22 D3DQ50
UniProt Related Accession:Q8WXI4
Molecular Weight:67,152 Da
NCBI Full Name:Acyl-coenzyme A thioesterase 11
NCBI Synonym Full Names:acyl-CoA thioesterase 11
NCBI Official Symbol:ACOT11��
NCBI Official Synonym Symbols:BFIT; THEA; THEM1; STARD14��
NCBI Protein Information:acyl-coenzyme A thioesterase 11; START domain containing 14; acyl-CoA thioester hydrolase 11; adipose-associated thioesterase; brown fat-inducible thioesterase; thioesterase, adipose associated; thioesterase superfamily member 1; StAR-related lipid transfer (START) domain containing 14
UniProt Protein Name:Acyl-coenzyme A thioesterase 11
UniProt Synonym Protein Names:Acyl-CoA thioester hydrolase 11; Adipose-associated thioesterase; Brown fat-inducible thioesterase; BFIT
Protein Family:Acyl-coenzyme A thioesterase
UniProt Gene Name:ACOT11��
UniProt Entry Name:ACO11_HUMAN
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