Enzymes Recombinant Proteins

Human ACAD8 Recombinant Protein (RPPB5766)

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SKU:
RPPB5766
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UKU7
Research Area:
Enzymes

Description

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Product Name:Human ACAD8 Recombinant Protein
Product Code:RPPB5766
Size:20µg
Species:Human
Target:ACAD8
Synonyms:Acyl-CoA dehydrogenase family member 8 mitochondrial, ACAD-8, Isobutyryl-CoA dehydrogenase, Activator-recruited cofactor 42 kDa component, ARC42, FLJ22590.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The ACAD8 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLVQTGHR SLTSCIDPSM GLNEEQKEFQ KVAFDFAARE MAPNMAEWDQ KELFPVDVMR KAAQLGFGGV YIQTDVGGSG LSRLDTSVIF EALATGCTST TAYISIHNMC AWMIDSFGNE EQRHKFCPPL CTMEKFASYC LTEPGSGSDA ASLLTSAKKQ GDHYILNGSK AFISGAGESD IYVVMCRTGG PGPKGISCIV VEKGTPGLSF GKKEKKVGWN SQPTRAVIFE DCAVPVANRI GSEGQGFLIA VRGLNGGRIN IASCSLGAAH ASVILTRDHL NVRKQFGEPL ASNQYLQFTL ADMATRLVAA RLMVRNAAVA LQEERKDAVA LCSMAKLFAT DECFAICNQA LQMHGGYGYL KDYAVQQYVR DSRVHQILEG SNEVMRILIS RSLLQE

Acyl CoA dehydrogenase is the enzymeused to catalyzethe first step of beta-oxidationin Fatty acid metabolism.Acyl-coenzyme A (CoA) dehydrogenases (ACADs) are a family of mitochondrial enzymes that catalyze the first dehydrogenation step in the bets-oxidation of fatty acyl-CoA derivatives. Several human ACADs exist and all ACADs catalyze the same initial dehydrogenation of the substrate at the beta-carbon atom and require electron transfer flavoprotein as an alectron acceptor. The predicted 415-amino acid ACAD8 protein contains many of the residues conserved in most other ACADs, including an active site glutamic acid residue and residues important for tetramer formation.

ACAD8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 416 amino acids (23-415) and having a molecular mass of 45.1kDa.ACAD8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009]
UniProt Code:Q9UKU7
NCBI GenInfo Identifier:26006699
NCBI Gene ID:27034
NCBI Accession:Q9UKU7.1
UniProt Secondary Accession:Q9UKU7
UniProt Related Accession:Q9UKU7
Molecular Weight:39kDa
NCBI Full Name:Isobutyryl-CoA dehydrogenase, mitochondrial
NCBI Synonym Full Names:acyl-CoA dehydrogenase family member 8
NCBI Official Symbol:ACAD8��
NCBI Official Synonym Symbols:ARC42; ACAD-8��
NCBI Protein Information:isobutyryl-CoA dehydrogenase, mitochondrial
UniProt Protein Name:
UniProt Synonym Protein Names:
Protein Family:Isobutyryl-CoA dehydrogenase
UniProt Gene Name:
UniProt Entry Name:
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