Human ABI3 Recombinant Protein (RPPB2694)

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SKU:
RPPB2694
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9P2A4

Description

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Product Name:Human ABI3 Recombinant Protein
Product Code:RPPB2694
Size:10µg
Species:Human
Target:ABI3
Synonyms:ABI Family Member 3, ABI Gene Family Member 3, New Molecule Including SH3, SSH3BP3, NESH.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ABI3 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAELQQL QEFEIPTGRE ALRGNHSALL RVADYCEDNY VQATDKRKAL EETMAFTTQA LASVAYQVGN LAGHTLRMLD LQGAALRQVE ARVSTLGQMV NMHMEKVARR EIGTLATVQR LPPGQKVIAP ENLPPLTPYC RRPLNFGCLD DIGHGIKDLS TQLSRTGTLS RKSIKAPATP ASATLGRPPR IPEPVHLPVV PDGRLSAASS ASSLASAGSA EGVGGAPTPK GQAAPPAPPL PSSLDPPPPP AAVEVFQRPP TLEELSPPPP DEELPLPLDL PPPPPLDGDE LGLPPPPPGF GPDEPSWVPA SYLEKVVTLY PYTSQKDNEL SFSEGTVICV TRRYSDGWCE GVSSEGTGFF PGNYVEPSC

ABI gene family member 3 (ABI3) is a member of the ABI family. Members of the ABI family encode proteins which contain a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. Abi family members are assumed to negatively regulate cell growth and transformation, including cellular transformation through v-Abl as well controlling as mediate cell motility by regulating actin polymerization in lamellipodia and filopodia. ABI3 impedes ectopic metastasis of tumor cells as well as cell migration, which is accomplished through interaction with p21-activated kinase.

ABI3 Human Recombinant produced in E. coli is a single polypeptide chain containing 389 amino acids (1-366) and having a molecular mass of 41.4 kDa.ABI3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ABI3: May inhibit tumor metastasis. In vitro, reduces cell motility. Belongs to the ABI family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 17q21.3Cellular Component: cytoplasm; intracellular; lamellipodium; membraneMolecular Function: protein bindingBiological Process: cell motility; peptidyl-tyrosine phosphorylation; regulation of cell migration
UniProt Protein Details:
NCBI Summary:This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:Q9P2A4
NCBI GenInfo Identifier:206597502
NCBI Gene ID:51225
NCBI Accession:NP_001128658.1
UniProt Secondary Accession:Q9P2A4,Q9H0P6, C9IZN8
UniProt Related Accession:Q9P2A4
Molecular Weight:38,450 Da
NCBI Full Name:ABI gene family member 3 isoform 2
NCBI Synonym Full Names:ABI family member 3
NCBI Official Symbol:ABI3��
NCBI Official Synonym Symbols:NESH; SSH3BP3��
NCBI Protein Information:ABI gene family member 3
UniProt Protein Name:ABI gene family member 3
UniProt Synonym Protein Names:New molecule including SH3; Nesh
Protein Family:ABI gene family
UniProt Gene Name:ABI3��
UniProt Entry Name:ABI3_HUMAN
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