Human ABCG2 Recombinant Protein (His tag)
- SKU:
- RPES5685
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
| Product Name: | Human ABCG2 Recombinant Protein (His tag) |
| Product Code: | RPES5685 |
| Size: | 20µg |
| Species: | Human |
| Expression Host: | E.coli |
| Synonyms: | Broad substrate specificity ATP-binding cassette transporter ABCG2, ABCG2, ATP-binding cassette sub-family G member 2, Breast cancer resistance protein, CDw338 |
| Mol Mass: | 32.89 kDa |
| AP Mol Mass: | 32 kDa |
| Tag: | N-His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Met 1-Gly 300 |
| Accession: | Q9UNQ0 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Hematopoietic stem cells are known to express a membrane transporter molecule, known as P-glycoprotein (Pgp), that is encoded by the multidrug resistance gene 1 (MDR1) . Expression of Pgp appears to confer a proliferative advantage to stem cells through its anti-apoptotic effects . An additional transporter molecule known as ABCG2 (ATP-binding cassette gene 2) or Bcrp1 (Breast cancer resistance protein 1), first identified in a breast cancer cell line , is expressed on stem cells . ABCG2 belongs to a family of molecules that span the cell membrane six times and can exist as either homo or hetero dimers linked by a short intracellular flexible linker region that plays an important role in the efflux of a wide range of substrates |
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