Cytokines Recombinant Proteins

Human 4 1BBR Recombinant Protein (RPPB0983)

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SKU:
RPPB0983
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q07011
Research Area:
Cytokines

Description

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Product Name:Human 4 1BBR Recombinant Protein
Product Code:RPPB0983
Size:20µg
Species:Human
Target:4 1BBR
Synonyms:Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor T-cell, antigen 4-1BB homolog, T-cell antigen ILA, CD137 antigen, CDw137, ILA, 4-1BB, MGC2172, 4-1BBR, TNFRSF9.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:4-1BBR protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMFERTRS LQDPCSNCPA GTFCDNNRNQ ICSPCPPNSF SSAGGQRTCD ICRQCKGVFR TRKECSSTSN AECDCTPGFH CLGAGCSMCE QDCKQGQELT KKGCKDCCFG TFNDQKRGIC RPWTNCSLDG KSVLVNGTKE RDVVCGPSPA DLSPGASSVT PPAPAREPGH SPQ

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

4-1BBR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 193 amino acids (18-186 a.a) and having a molecular mass of 20kDa.4-1BBR is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function:cytokine binding; receptor activity

Biological Process: negative regulation of cell proliferation; apoptosis

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Code:Q07011
NCBI GenInfo Identifier:728738
NCBI Gene ID:3604
NCBI Accession:Q07011.1
UniProt Related Accession:Q07011,AAB34924
Molecular Weight:27,899 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 9
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 9
NCBI Official Symbol:TNFRSF9��
NCBI Official Synonym Symbols:ILA; 4-1BB; CD137; CDw137��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 9
UniProt Synonym Protein Names:4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137
UniProt Gene Name:TNFRSF9��
UniProt Entry Name:TNR9_HUMAN
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