HSP27/HSPB1 Polyclonal Antibody (CAB21461)
- SKU:
- CAB21461
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | HSP27/HSPB1 Polyclonal Antibody |
| Product Code: | CAB21461 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:2000, IF/ICC 1:50-1:200, IP 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | HepG2, HeLa |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton, spindle |
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human HSP27/HSPB1 (NP_001531.1). |
| Sequence: | MTERR VPFSL LRGPS WDPFR DWYPH SRLFD QAFGL PRLPE EWSQW LGGSS WPGYV RPLPP AAIES PAVAA PAYSR ALSRQ LSSGV SEIRH TADRW RVSLD VNHFA PDELT VKTKD GVVEI |
| Synonyms: | CMT2F, HMN2B, HSP27, HSP28, Hsp25, SRP27, HS.76067, HEL-S-102 |
| Calculated MW: | 23kDa |
| Observed MW: | Refer to figures |
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