Antibody Name:	HSD17B14 Antibody (PACO16494)
Antibody SKU:	PACO16494
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Fusion protein of human HSD17B14

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16494(HSD17B14 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16494(HSD17B14 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).

Background:

17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acid, , prostaglandins, and xenobiotics. Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).

Synonyms:

hydroxysteroid (17-beta) dehydrogenase 14

UniProt Protein Function:	HSD17B14: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.Protein type: EC 1.1.1.-; OxidoreductaseChromosomal Location of Human Ortholog: 19q13.33Cellular Component: cytosolMolecular Function: estradiol 17-beta-dehydrogenase activity; identical protein binding; protein binding; testosterone 17-beta-dehydrogenase (NADP+) activityBiological Process: estrogen biosynthetic process; steroid catabolic process
UniProt Protein Details:
NCBI Summary:	17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
UniProt Code:	Q9BPX1
NCBI GenInfo Identifier:	59889578
NCBI Gene ID:	51171
NCBI Accession:	NP_057330.2
UniProt Secondary Accession:	Q9BPX1,Q9UKU3
UniProt Related Accession:	Q9BPX1
Molecular Weight:	44.3kD
NCBI Full Name:	17-beta-hydroxysteroid dehydrogenase 14
NCBI Synonym Full Names:	hydroxysteroid 17-beta dehydrogenase 14
NCBI Official Symbol:	HSD17B14
NCBI Official Synonym Symbols:	DHRS10; SDR47C1; retSDR3
NCBI Protein Information:	17-beta-hydroxysteroid dehydrogenase 14
UniProt Protein Name:	17-beta-hydroxysteroid dehydrogenase 14
UniProt Synonym Protein Names:	17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1
Protein Family:	17-beta-hydroxysteroid dehydrogenase
UniProt Gene Name:	HSD17B14
UniProt Entry Name: