HSD17B11 Antibody (PACO39126)
- SKU:
- PACO39126
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HSD17B11 Antibody (PACO39126) |
| Antibody SKU: | PACO39126 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Estradiol 17-beta-dehydrogenase 11 protein (20-300AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: HSD17B11 antibody at 10µg/ml + Mouse lung tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 33 kDa. Observed band size: 33 kDa. |
| Background: | Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. |
| Synonyms: | Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2), HSD17B11, DHRS8 PAN1B SDR16C2 |
| UniProt Protein Function: | HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.Protein type: Secreted, signal peptide; Secreted; Oxidoreductase; EC 1.1.1.62Chromosomal Location of Human Ortholog: 4q22.1Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particleMolecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activityBiological Process: androgen catabolic process; estrogen biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q8NBQ5 |
| NCBI GenInfo Identifier: | 296439374 |
| NCBI Gene ID: | 51170 |
| NCBI Accession: | Q8NBQ5.3 |
| UniProt Secondary Accession: | Q8NBQ5,Q96HF6, Q9UKU4 |
| UniProt Related Accession: | Q8NBQ5 |
| Molecular Weight: | 32,936 Da |
| NCBI Full Name: | Estradiol 17-beta-dehydrogenase 11 |
| NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 11 |
| NCBI Official Symbol: | HSD17B11 |
| NCBI Official Synonym Symbols: | DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI |
| NCBI Protein Information: | estradiol 17-beta-dehydrogenase 11 |
| UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 11 |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2; Short chain dehydrogenase/reductase family 16C member 2 |
| Protein Family: | Estradiol 17 beta-dehydrogenase |
| UniProt Gene Name: | HSD17B11 |
| UniProt Entry Name: | DHB11_HUMAN |
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