Description
Antibody Name: | HSBP1 Antibody (PACO09803) |
Antibody SKU: | PACO09803 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human HSBP1 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | heat shock factor binding protein 1;HSBP1;DKFZp686D1664;DKFZp686O24200;NPC-A-13 ; |
UniProt Protein Function: | HSBP1: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. Belongs to the HSBP1 family.Chromosomal Location of Human Ortholog: 16q23.3Cellular Component: nucleoplasm; cytoskeleton; nucleusMolecular Function: transcription corepressor activityBiological Process: muscle contraction; negative regulation of transcription from RNA polymerase II promoter |
UniProt Protein Details: | |
NCBI Summary: | The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75506 |
NCBI GenInfo Identifier: | 119615920 |
NCBI Gene ID: | 3281 |
NCBI Accession: | EAW95514.1 |
UniProt Secondary Accession: | O75506,Q53XA8, Q7Z5Z3 |
UniProt Related Accession: | O75506 |
Molecular Weight: | |
NCBI Full Name: | heat shock factor binding protein 1 |
NCBI Synonym Full Names: | heat shock factor binding protein 1 |
NCBI Official Symbol: | HSBP1 |
NCBI Official Synonym Symbols: | NPC-A-13 |
NCBI Protein Information: | heat shock factor-binding protein 1; nasopharyngeal carcinoma-associated antigen 13 |
UniProt Protein Name: | Heat shock factor-binding protein 1 |
UniProt Synonym Protein Names: | Nasopharyngeal carcinoma-associated antigen 13; NPC-A-13 |
Protein Family: | Heat shock factor-binding protein |
UniProt Gene Name: | HSBP1 |
UniProt Entry Name: | HSBP1_HUMAN |