HS3ST1 Antibody (PACO27453)
- SKU:
- PACO27453
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HS3ST1 Antibody (PACO27453) |
| Antibody SKU: | PACO27453 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Heparan sulfate glucosamine 3-O-sulfotransferase 1 protein (21-307AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human heart tissue using PACO27453 at dilution of 1:100. |
| Background: | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. |
| Synonyms: | Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1), HS3ST1, 3OST 3OST1 |
| UniProt Protein Function: | HS3ST1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Belongs to the sulfotransferase 1 family.Protein type: EC 2.8.2.23; Transferase; Glycan Metabolism - heparan sulfate biosynthesisChromosomal Location of Human Ortholog: 4p16Cellular Component: Golgi lumen; integral to membraneMolecular Function: sulfotransferase activity; heparin-glucosamine 3-O-sulfotransferase activityBiological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14792 |
| NCBI GenInfo Identifier: | 4826764 |
| NCBI Gene ID: | 9957 |
| NCBI Accession: | NP_005105.1 |
| UniProt Secondary Accession: | O14792,Q6PEY8, B3KUA6 |
| UniProt Related Accession: | O14792 |
| Molecular Weight: | 35,773 Da |
| NCBI Full Name: | heparan sulfate glucosamine 3-O-sulfotransferase 1 |
| NCBI Synonym Full Names: | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
| NCBI Official Symbol: | HS3ST1 |
| NCBI Official Synonym Symbols: | 3OST; 3OST1 |
| NCBI Protein Information: | heparan sulfate glucosamine 3-O-sulfotransferase 1; 3-OST-1; h3-OST-1; heparan sulfate 3-O-sulfotransferase 1; heparin-glucosamine 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1 |
| UniProt Protein Name: | Heparan sulfate glucosamine 3-O-sulfotransferase 1 |
| UniProt Synonym Protein Names: | Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; 3-OST-1; Heparan sulfate 3-O-sulfotransferase 1; h3-OST-1 |
| Protein Family: | |
| UniProt Gene Name: | HS3ST1 |
| UniProt Entry Name: | HS3S1_HUMAN |
| Antibodies |
| HS3ST1 Antibody (PACO09802) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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