HRK Antibody (PACO19792)
- SKU:
- PACO19792
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | HRK Antibody (PACO19792) |
| Antibody SKU: | PACO19792 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human HRK |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19792(HRK Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19792(HRK Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. |
| Synonyms: | harakiri, BCL2 interacting protein (contains only BH3 domain) |
| UniProt Protein Function: | HRK: Promotes apoptosis.Protein type: Membrane protein, integral; ApoptosisChromosomal Location of Human Ortholog: 12q24.22Cellular Component: mitochondrion; integral to membraneMolecular Function: protein bindingBiological Process: apoptosis; positive regulation of apoptosis; positive regulation of protein homooligomerization |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] |
| UniProt Code: | O00198 |
| NCBI GenInfo Identifier: | 4504493 |
| NCBI Gene ID: | 8739 |
| NCBI Accession: | NP_003797 |
| UniProt Secondary Accession: | O00198 |
| UniProt Related Accession: | O00198 |
| Molecular Weight: | 9,884 Da |
| NCBI Full Name: | activator of apoptosis harakiri |
| NCBI Synonym Full Names: | harakiri, BCL2 interacting protein |
| NCBI Official Symbol: | HRK |
| NCBI Official Synonym Symbols: | DP5; HARAKIRI |
| NCBI Protein Information: | activator of apoptosis harakiri; death protein 5; BCL2-interacting protein; activator of apoptosis Hrk; neuronal death protein DP5; BH3-interacting domain-containing protein 3; harakiri, BCL2 interacting protein (contains only BH3 domain) |
| UniProt Protein Name: | Activator of apoptosis harakiri |
| UniProt Synonym Protein Names: | BH3-interacting domain-containing protein 3; Neuronal death protein DP5 |
| Protein Family: | Activator of apoptosis harakiri |
| UniProt Gene Name: | HRK |
| UniProt Entry Name: | HRK_HUMAN |
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